Phenotypes associated with this allele

• Allele Symbol: Dnase1l2^{tm1(KOMP)Wtsi}
• Allele Name: targeted mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362265
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dnase1l2^tm1(KOMP)Wtsi/Dnase1l2^tm1(KOMP)Wtsi	C57BL/6N-Dnase1l2^tm1(KOMP)Wtsi/Wtsi	MGI:5631065
hm2	Dnase1l2^tm1(KOMP)Wtsi/Dnase1l2^tm1(KOMP)Wtsi	involves: C57BL/6N	MGI:5544016

Genotype
MGI:5631065

hm1

• Allelic Composition: Dnase1l2^{tm1(KOMP)Wtsi}/Dnase1l2^{tm1(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Dnase1l2^{tm1(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0296_2_A10

Data Sources

IMPC Data for Dnase1l2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - RBRC

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - RBRC

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - RBRC

decreased body length ( J:211773 )

IMPC - RBRC

limbs/digits/tail

abnormal autopod morphology ( J:211773 )

IMPC - RBRC

abnormal digit morphology ( J:211773 )

IMPC - RBRC

brachydactyly ( J:211773 )

IMPC - RBRC

short tibia ( J:211773 )

IMPC - RBRC

abnormal tail morphology ( J:211773 )

IMPC - RBRC

abnormal tail length ( J:211773 )

IMPC - RBRC

skeleton

short tibia ( J:211773 )

IMPC - RBRC

abnormal bone structure ( J:211773 )

♀

IMPC - RBRC

decreased bone mineral content ( J:211773 )

♀

IMPC - RBRC

Genotype
MGI:5544016

hm2

• Allelic Composition: Dnase1l2^{tm1(KOMP)Wtsi}/Dnase1l2^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0296_2_A10

behavior/neurological

decreased grip strength ( J:200082 )

♀ • in female mice

skeleton

fused joints ( J:200082 )

• ankylosis of the metacarpophalangeal joints