Phenotypes associated with this allele

• Allele Symbol: Wdr3^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362309
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Wdr3^tm1a(KOMP)Wtsi/Wdr3^tm1a(KOMP)Wtsi	C57BL/6N-Wdr3^tm1a(KOMP)Wtsi	MGI:7446674
ht2	Wdr3^tm1a(KOMP)Wtsi/Wdr3^+	C57BL/6N-Wdr3^tm1a(KOMP)Wtsi	MGI:7446675

Genotype
MGI:7446674

hm1

• Allelic Composition: Wdr3^{tm1a(KOMP)Wtsi}/Wdr3^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Wdr3^{tm1a(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:334057 )

• no homozygous mutant mice are born from heterozygous intercrosses

Genotype
MGI:7446675

ht2

• Allelic Composition: Wdr3^{tm1a(KOMP)Wtsi}/Wdr3⁺
• Genetic Background: C57BL/6N-Wdr3^{tm1a(KOMP)Wtsi}

behavior/neurological

behavior/neurological phenotype ( J:334057 )

♂N • adult mice show normal placing behavior in a visual placing response test, and exhibit no changes in the time spent in the central area of the open field suggesting normal anxiety levels

increased locomotor activity ( J:334057 )

♂ • in the open field test, adult male mice show a slight but significant increase in total distance traveled and in distance traveled per minute along with a significant reduction in the % of resting time, suggesting increased spontaneous locomotor activity

♂ • walking speed remains unaffected

growth/size/body

growth/size/body region phenotype ( J:334057 )

♂N • male mice show normal developmental weight gain and no differences in body weight at 10 weeks of age relative to age-matched wild-type controls

nervous system

nervous system phenotype ( J:334057 )

♂N • adult brain anatomy is grossly normal with no detectable changes in hippocampus and cerebral cortex histology

♂N • Real-time PCR analysis showed normal expression levels of 18S rRNA in the cerebral cortex, hippocampus and cerebellum

vision/eye

vision/eye phenotype ( J:334057 )

♂N • adult mice exhibit normal visual function in a visual placing response test