Phenotypes associated with this allele

• Allele Symbol: Rhobtb3^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362349
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhobtb3^tm1a(KOMP)Wtsi/Rhobtb3^tm1a(KOMP)Wtsi	B6JTyr;B6N-Rhobtb3^tm1a(KOMP)Wtsi/Wtsi	MGI:5781722
hm2	Rhobtb3^tm1a(KOMP)Wtsi/Rhobtb3^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5791062
hm3	Rhobtb3^tm1a(KOMP)Wtsi/Rhobtb3^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5752793

Genotype
MGI:5781722

hm1

• Allelic Composition: Rhobtb3^{tm1a(KOMP)Wtsi}/Rhobtb3^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Rhobtb3^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0042_1_G09

Data Sources

IMPC Data for Rhobtb3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:175295 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:175295 )

♂

IMPC - WTSI

abnormal snout morphology ( J:175295 )

♂

IMPC - WTSI

growth/size/body

abnormal tooth morphology ( J:175295 )

♂

IMPC - WTSI

abnormal snout morphology ( J:175295 )

♂

IMPC - WTSI

decreased lean body mass ( J:175295 )

IMPC - WTSI

decreased body weight ( J:175295 )

IMPC - WTSI

decreased body length ( J:175295 )

IMPC - WTSI

hematopoietic system

increased mean corpuscular volume ( J:175295 )

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:175295 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:175295 )

♂

IMPC - WTSI

decreased bone mineral content ( J:175295 )

IMPC - WTSI

abnormal joint morphology ( J:175295 )

♂

IMPC - WTSI

Genotype
MGI:5791062

hm2

• Allelic Composition: Rhobtb3^{tm1a(KOMP)Wtsi}/Rhobtb3^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0042_1_G09

behavior/neurological

decreased grip strength ( J:213427 )

craniofacial

abnormal tooth morphology ( J:213427 )

growth/size/body

abnormal tooth morphology ( J:213427 )

decreased body weight ( J:213427 )

decreased body length ( J:213427 )

limbs/digits/tail

abnormal patella morphology ( J:213427 )

mortality/aging

decreased survivor rate ( J:213427 )

reproductive system

reduced fertility ( J:213427 )

skeleton

abnormal tooth morphology ( J:213427 )

abnormal patella morphology ( J:213427 )

abnormal joint morphology ( J:213427 )

Genotype
MGI:5752793

hm3

• Allelic Composition: Rhobtb3^{tm1a(KOMP)Wtsi}/Rhobtb3^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0042_1_G09

mortality/aging

preweaning lethality, incomplete penetrance ( J:226884 )

• fewer than expected mice are present at weaning

growth/size/body

decreased body weight ( J:226884 )

• until postnatal week 12 in female mice

• persisting beyond week 12 in male mice

postnatal growth retardation ( J:226884 )

• until postnatal week 12 in female mice

• persisting beyond 12 week in male mice

reproductive system

decreased testis weight ( J:226884 )

♂

cardiovascular system

decreased heart weight ( J:226884 )

♂ • slightly in male mice

renal/urinary system

decreased kidney weight ( J:226884 )

• slightly in female and male mice

hematopoietic system

decreased spleen weight ( J:226884 )

♂ • slightly in male mice

digestive/alimentary system

digestive/alimentary phenotype ( J:226884 )

N • mice exhibit normal structure of all layers of the small and large intestine, number of goblet cells and villi length

endocrine/exocrine glands

decreased testis weight ( J:226884 )

♂

immune system

decreased spleen weight ( J:226884 )

♂ • slightly in male mice