Phenotypes associated with this allele

• Allele Symbol: Eps15^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362352
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eps15^tm1a(KOMP)Wtsi/Eps15^tm1a(KOMP)Wtsi	B6JTyr;B6N-Eps15^tm1a(KOMP)Wtsi/Wtsi	MGI:5781620
hm2	Eps15^tm1a(KOMP)Wtsi/Eps15^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790966

Genotype
MGI:5781620

hm1

• Allelic Composition: Eps15^{tm1a(KOMP)Wtsi}/Eps15^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Eps15^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0056_1_A10

Data Sources

IMPC Data for Eps15

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:175295 )

IMPC - WTSI

increased circulating LDL cholesterol level ( J:175295 )

IMPC - WTSI

growth/size/body

increased body weight ( J:165965 )

IMPC - WTSI

immune system

decreased leukocyte cell number ( J:165965 )

IMPC - WTSI

hematopoietic system

decreased mean corpuscular hemoglobin ( J:165965 )

♀

IMPC - WTSI

decreased leukocyte cell number ( J:165965 )

IMPC - WTSI

Genotype
MGI:5790966

hm2

• Allelic Composition: Eps15^{tm1a(KOMP)Wtsi}/Eps15^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0056_1_A10

hematopoietic system

decreased mean corpuscular hemoglobin ( J:213427 )

decreased mean corpuscular hemoglobin concentration ( J:213427 )

immune system

dermatitis ( J:213427 )

• epidermitis/dermatitis seen in 2/4 animals

integument

dermatitis ( J:213427 )

• epidermitis/dermatitis seen in 2/4 animals