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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rgcctm1(KOMP)Wtsi
targeted mutation 1, Wellcome Trust Sanger Institute
MGI:4362711
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rgcctm1(KOMP)Wtsi/Rgcctm1(KOMP)Wtsi involves: C57BL/6N MGI:5695594


Genotype
MGI:5695594
hm1
Allelic
Composition
Rgcctm1(KOMP)Wtsi/Rgcctm1(KOMP)Wtsi
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rgcctm1(KOMP)Wtsi mutation (1 available); any Rgcc mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some still births observed at E16.5
• ratio of births diverges from a Mendelian ratio: +/+=26%, +/-=49%, -/-=15%, stillbirths=10%

growth/size/body
• 27% lighter at birth than control littermates
• body weight difference remains stable until 4 weeks of age (22% lighter than wild-type controls)
• size difference is less dramatic after 5 weeks
• however, growth index is similar to that in wild-type controls during the first 4 weeks
• E16.5 embryos are smaller than wild-type
• E16.5 fetal weight is 80% of wild-type controls
• fetal growth restriction due to impaired placental angiogenesis

embryo
• fewer fetal capillaries with bigger vessel lumens in the midline of the placenta labyrinth
• E11.5 yolk sacs display fewer and smaller blood vessels than wild-type yolk sacs
• center but not the periphery of the placental labyrinth is significantly reduced in size
• E16.5 placentas are smaller than wild-type
• E16.5 placenta weight is 82% of wild-type controls

cardiovascular system
• fewer fetal capillaries with bigger vessel lumens in the midline of the placenta labyrinth
• E11.5 yolk sacs display fewer and smaller blood vessels than wild-type yolk sacs





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory