Phenotypes associated with this allele

• Allele Symbol: Sec24a^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362779
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sec24a^tm1a(KOMP)Wtsi/Sec24a^tm1a(KOMP)Wtsi	B6JTyr;B6N-Sec24a^tm1a(KOMP)Wtsi/Wtsi	MGI:5781733
hm2	Sec24a^tm1a(KOMP)Wtsi/Sec24a^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5791063

Genotype
MGI:5781733

hm1

• Allelic Composition: Sec24a^{tm1a(KOMP)Wtsi}/Sec24a^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Sec24a^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0099_2_E04

Data Sources

IMPC Data for Sec24a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:175295 )

♂

IMPC - WTSI

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

increased blood urea nitrogen level ( J:175295 )

IMPC - WTSI

decreased circulating cholesterol level ( J:175295 )

♂

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:175295 )

♂

IMPC - WTSI

decreased circulating LDL cholesterol level ( J:175295 )

♂

IMPC - WTSI

decreased circulating free fatty acids level ( J:175295 )

IMPC - WTSI

decreased circulating alkaline phosphatase level ( J:175295 )

IMPC - WTSI

Genotype
MGI:5791063

hm2

• Allelic Composition: Sec24a^{tm1a(KOMP)Wtsi}/Sec24a^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0099_2_E04

homeostasis/metabolism

decreased circulating cholesterol level ( J:213427 )

decreased circulating LDL cholesterol level ( J:213427 )

liver/biliary system

abnormal liver physiology ( J:213427 )

• absent or minimal hepatic lipidosis