Phenotypes associated with this allele

• Allele Symbol: Meioc^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362869
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Meioc^tm1a(KOMP)Wtsi/Meioc^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N * NMRI	MGI:5897825
cx2	Meioc^tm1a(KOMP)Wtsi/Meioc^tm1a(KOMP)Wtsi Spo11^tm1Mjn/Spo11^tm1Mjn	involves: 129X1/SvJ * C57BL/6N	MGI:5897826

Genotype
MGI:5897825

hm1

• Allelic Composition: Meioc^{tm1a(KOMP)Wtsi}/Meioc^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N * NMRI

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

decreased oocyte number ( J:231231 )

♀ • in the perinatal period

absent oocytes ( J:231231 )

♀ • at early as P8

decreased male germ cell number ( J:231231 )

♂ • 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia

azoospermia ( J:231231 )

♂ • absence of spermatozoon in the seminiferous tubules and epididymides

abnormal female meiosis I arrest ( J:231231 )

♀

arrest of male meiosis ( J:231231 )

♂ • 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia

abnormal synaptonemal complex ( J:231231 )

increased male germ cell apoptosis ( J:231231 )

♂

absent ovarian follicles ( J:231231 )

♀

small ovary ( J:231231 )

♀ • barely detectible

small testis ( J:231231 )

♂ • barely detectible

female infertility ( J:231231 )

♀

male infertility ( J:231231 )

♂

homeostasis/metabolism

abnormal double-strand DNA break repair ( J:231231 )

• during meiosis

cellular

decreased oocyte number ( J:231231 )

♀ • in the perinatal period

absent oocytes ( J:231231 )

♀ • at early as P8

decreased male germ cell number ( J:231231 )

♂ • 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia

azoospermia ( J:231231 )

♂ • absence of spermatozoon in the seminiferous tubules and epididymides

abnormal female meiosis I arrest ( J:231231 )

♀

arrest of male meiosis ( J:231231 )

♂ • 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia

abnormal synaptonemal complex ( J:231231 )

increased male germ cell apoptosis ( J:231231 )

♂

abnormal double-strand DNA break repair ( J:231231 )

• during meiosis

endocrine/exocrine glands

absent ovarian follicles ( J:231231 )

♀

small ovary ( J:231231 )

♀ • barely detectible

small testis ( J:231231 )

♂ • barely detectible

Genotype
MGI:5897826

cx2

• Allelic Composition: Meioc^{tm1a(KOMP)Wtsi}/Meioc^{tm1a(KOMP)Wtsi}; Spo11^tm1Mjn/Spo11^tm1Mjn
• Genetic Background: involves: 129X1/SvJ * C57BL/6N

reproductive system

absent oocytes ( J:231231 )

azoospermia ( J:231231 )

arrest of male meiosis ( J:231231 )

• in early meiosis prophase I

cellular

absent oocytes ( J:231231 )

azoospermia ( J:231231 )

arrest of male meiosis ( J:231231 )

• in early meiosis prophase I