Phenotypes associated with this allele

• Allele Symbol: Rhbdf2^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362881
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rhbdf2^tm1a(KOMP)Wtsi/Rhbdf2^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5437488
ht2	Rhbdf2^m1Btlr/Rhbdf2^tm1a(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5437489
cx3	Rhbdf1^em1Mvw/Rhbdf1^em1Mvw Rhbdf2^tm1a(KOMP)Wtsi/Rhbdf2^tm1a(KOMP)Wtsi	B6.Cg-Rhbdf1^em1Mvw Rhbdf2^tm1a(KOMP)Wtsi/Mvw	MGI:6449217

Genotype
MGI:5437488

hm1

• Allelic Composition: Rhbdf2^{tm1a(KOMP)Wtsi}/Rhbdf2^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0208_1_D12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased tumor necrosis factor secretion ( J:187583 )

• peritoneal macrophage exhibit impaired TLR-induced TNFalpha response

Genotype
MGI:5437489

ht2

• Allelic Composition: Rhbdf2^m1Btlr/Rhbdf2^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0208_1_D12

immune system

decreased tumor necrosis factor secretion ( J:187583 )

• peritoneal macrophage exhibit impaired TLR-induced TNFalpha response

Genotype
MGI:6449217

cx3

• Allelic Composition: Rhbdf1^em1Mvw/Rhbdf1^em1Mvw; Rhbdf2^{tm1a(KOMP)Wtsi}/Rhbdf2^{tm1a(KOMP)Wtsi}
• Genetic Background: B6.Cg-Rhbdf1^em1Mvw Rhbdf2^{tm1a(KOMP)Wtsi}/Mvw

integument

waved hair ( J:291556 )

vision/eye

eyelids open at birth ( J:291556 )

cardiovascular system

cardiovascular system phenotype ( J:291556 )

N • although double mutants for true null alleles are subviable with brain and heart defects, these mice do not have those defects