Phenotypes associated with this allele

• Allele Symbol: Map3k13^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362915
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Map3k13^tm1a(KOMP)Wtsi/Map3k13^tm1a(KOMP)Wtsi	C57BL/6N-Map3k13^tm1a(KOMP)Wtsi	MGI:6780150

Genotype
MGI:6780150

cn1

• Allelic Composition: Map3k13^{tm1a(KOMP)Wtsi}/Map3k13^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Map3k13^{tm1a(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:236918 )

• primary cerebellar granule neurons (CGNs) purified from mutant mice and infected with AAV-GFP-Cre show a ~30 reduction in c-Jun N-terminal kinase (JNK) activation by 5 days in vitro (DIV)

abnormal axon extension ( J:236918 )

• in vitro, CGNs isolated from P7 mutant mice and co-transfected with pMAX-GFP and pCAG-Cre (to generate GFP-labeled Map3k13 knockout CGNs) show a ~35% reduction in maximum axon length and a ~40% reduction in total neurite length

• however, no effect on branching or total number of neurites is observed

nervous system

abnormal axon extension ( J:236918 )

• in vitro, CGNs isolated from P7 mutant mice and co-transfected with pMAX-GFP and pCAG-Cre (to generate GFP-labeled Map3k13 knockout CGNs) show a ~35% reduction in maximum axon length and a ~40% reduction in total neurite length

• however, no effect on branching or total number of neurites is observed