All Phenotypes Mysm1<tm1a(KOMP)Wtsi> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mysm1^{tm1a(KOMP)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4362924

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}	C57BL/6-Mysm1^{tm1a(KOMP)Wtsi}	MGI:5641692
hm2	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}	Not Specified	MGI:5449983
ht3	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺	Not Specified	MGI:5449985

Allelic Composition	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}
Genetic Background	C57BL/6-Mysm1^{tm1a(KOMP)Wtsi}
Cell Lines	EPD0019_1_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1^{tm1a(KOMP)Wtsi} mutation (2 available); any Mysm1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

belly spot ( J:209956 , J:232539 )

abnormal hair follicle morphology ( J:209956 )

• abnormalities in the hair follicles

distorted hair follicle pattern ( J:209956 , J:232539 )

• abnormal hair follicle patterning, with hair follicles no longer arranged as staggered rows of triplets (J:209956)

• defects in hair follicle organization and associated structures (J:232539)

abnormal hair cycle ( J:209956 )

• the hair follicle cycle is disturbed, with most hair follicles in telogen

abnormal epidermal layer morphology ( J:209956 )

• abnormalities in the interfollicular epidermis

• within the interfollicular epidermis, the scale pattern is completely disrupted, although regions of scale differentiation lacking the granular layer can still be seen

increased foot pad pigmentation ( J:232539 )

• foot pad hyperpigmentation

decreased tail pigmentation ( J:209956 , J:232539 )

• white tails (J:209956)

limbs/digits/tail

increased foot pad pigmentation ( J:232539 )

• foot pad hyperpigmentation

abnormal hindlimb morphology ( J:232539 )

abnormal tail morphology ( J:209956 )

decreased tail pigmentation ( J:209956 , J:232539 )

• white tails (J:209956)

short tail ( J:232539 )

curly tail ( J:232539 )

kinked tail ( J:209956 )

pigmentation

belly spot ( J:209956 , J:232539 )

increased foot pad pigmentation ( J:232539 )

• foot pad hyperpigmentation

decreased tail pigmentation ( J:209956 , J:232539 )

• white tails (J:209956)

Allelic Composition	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1^{tm1a(KOMP)Wtsi}
Genetic Background	Not Specified
Cell Lines	EPD0019_1_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1^{tm1a(KOMP)Wtsi} mutation (2 available); any Mysm1 mutation (44 available)

Data Sources

IMPC Data for Mysm1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal behavior ( J:165965 )

IMPC - HMGU

abnormal coping response ( J:165965 )

IMPC - HMGU

tremors ( J:165965 )

IMPC - HMGU

trunk curl ( J:165965 )

IMPC - HMGU

abnormal gait ( J:165965 )

IMPC - HMGU

decreased locomotor activity ( J:165965 )

IMPC - HMGU

hyperactivity ( J:165965 )

IMPC - HMGU

growth/size/body

decreased lean body mass ( J:165965 )

IMPC - HMGU

decreased body weight ( J:165965 )

IMPC - HMGU

abnormal body length ( J:165965 )

IMPC - HMGU

decreased body length ( J:165965 )

IMPC - HMGU

hematopoietic system

decreased erythrocyte cell number ( J:165965 )

IMPC - HMGU

decreased hematocrit ( J:165965 )

IMPC - HMGU

decreased hemoglobin content ( J:165965 )

IMPC - HMGU

increased mean corpuscular hemoglobin concentration ( J:165965 )

IMPC - HMGU

increased mean corpuscular volume ( J:165965 )

IMPC - HMGU

increased granulocyte number ( J:165965 )

IMPC - HMGU

thrombocytosis ( J:165965 )

IMPC - HMGU

increased T cell number ( J:165965 )

IMPC - HMGU

decreased leukocyte cell number ( J:165965 )

IMPC - HMGU

decreased B cell number ( J:165965 )

IMPC - HMGU

decreased mature B cell number ( J:165965 )

IMPC - HMGU

increased IgG2b level ( J:165965 )

IMPC - HMGU

homeostasis/metabolism

decreased circulating cholesterol level ( J:165965 )

IMPC - HMGU

decreased circulating triglyceride level ( J:165965 )

IMPC - HMGU

increased circulating phosphate level ( J:165965 )

IMPC - HMGU

increased circulating alkaline phosphatase level ( J:165965 )

IMPC - HMGU

immune system

increased granulocyte number ( J:165965 )

IMPC - HMGU

increased T cell number ( J:165965 )

IMPC - HMGU

decreased leukocyte cell number ( J:165965 )

IMPC - HMGU

decreased B cell number ( J:165965 )

IMPC - HMGU

decreased mature B cell number ( J:165965 )

IMPC - HMGU

increased IgG2b level ( J:165965 )

IMPC - HMGU

integument

abnormal coat/ hair morphology ( J:165965 )

IMPC - HMGU

abnormal coat/hair pigmentation ( J:165965 )

IMPC - HMGU

limbs/digits/tail

abnormal autopod morphology ( J:165965 )

IMPC - HMGU

abnormal hindlimb morphology ( J:165965 )

IMPC - HMGU

abnormal tail morphology ( J:165965 )

IMPC - HMGU

curly tail ( J:165965 )

IMPC - HMGU

kinked tail ( J:165965 )

IMPC - HMGU

pigmentation

abnormal coat/hair pigmentation ( J:165965 )

IMPC - HMGU

skeleton

abnormal vertebrae morphology ( J:165965 )

IMPC - HMGU

abnormal bone structure ( J:165965 )

IMPC - HMGU

abnormal bone mineralization ( J:165965 )

IMPC - HMGU

Allelic Composition	Mysm1^{tm1a(KOMP)Wtsi}/Mysm1⁺
Genetic Background	Not Specified
Cell Lines	EPD0019_1_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mysm1^{tm1a(KOMP)Wtsi} mutation (2 available); any Mysm1 mutation (44 available)

Data Sources

IMPC Data for Mysm1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased mean corpuscular volume ( J:165965 )

IMPC - HAR

homeostasis/metabolism

decreased circulating triglyceride level ( J:165965 )

IMPC - HAR

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24