Phenotypes associated with this allele

• Allele Symbol: Tgm4^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4362984
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgm4^tm1a(KOMP)Wtsi/Tgm4^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5494666

Genotype
MGI:5494666

hm1

• Allelic Composition: Tgm4^{tm1a(KOMP)Wtsi}/Tgm4^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0098_3_E12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

impaired fertilization ( J:195173 )

♂ • male mice fertilize fewer oocytes than wild-type mice

♂ • male mice sire fewer litters than wild-type mice

abnormal male reproductive system physiology ( J:195173 )

♂ • male mice fail to form copulatory plug demonstrating impaired seminal fluid coagulation

♂ • ejaculate migration within the female reproductive tract is impaired

♂ • however, mice exhibit normal copulatory behavior, sperm count, testes weight and seminal vesicle weight

behavior/neurological

failure of copulatory plug deposition ( J:195173 )

♂ • males fail to form a copulatory plug