Analysis Tools
behavior/neurological
| N |
• mice exhibit no deficits in Pavlovian conditioning and semantic memory as assessed, respectively, in cued and contextual fear conditioning and in an object recognition task
• anxiety, exploration and locomotion appear unaffected, as assessed in the elevated plus maze and open field tests
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• in the Morris water maze, 9-month-old mice show normal escape learning during training trials; however, in the spatial memory probe test, after 4 days of acquisition training, mice perform at a chance level in the search for the platform with significantly less time spent in the target quadrant than age-matched wild-type controls
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nervous system
| N |
• at 9 months of age, mice show no morphological changes in brain tissues including forebrain, hippocampus, cerebral cortex and thalamus
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