Phenotypes associated with this allele

• Allele Symbol: Adamts7^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363113
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adamts7^tm1a(KOMP)Wtsi/Adamts7^tm1a(KOMP)Wtsi	C57BL/6-Adamts7^tm1a(KOMP)Wtsi	MGI:5800299
hm2	Adamts7^tm1a(KOMP)Wtsi/Adamts7^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:5763181

Genotype
MGI:5800299

hm1

• Allelic Composition: Adamts7^{tm1a(KOMP)Wtsi}/Adamts7^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6-Adamts7^{tm1a(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased hepatocyte proliferation ( J:221183 )

• after feeding a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet for 12 days to induce liver injury, mice show a 40% decrease of Ki-67+ hepatocytes relative to similarly treated wild-type controls

abnormal oval cell physiology ( J:221183 )

• after feeding a DDC diet for 12 days, mice show a ~34% increase in oval cell (OC) proliferation within OC compartments relative to similarly treated wild-type controls

homeostasis/metabolism

increased collagen level ( J:221183 )

• at day 12 of DDC treatment, mice show a ~19% increase in hepatic collagen production relative to wild-type controls, as determined by a hydroxyproline assay

abnormal response to injury ( J:221183 )

• mice show a higher level of connective tissue growth factor (CTGF) protein accumulation and enhanced oval cell proliferation and biliary fibrosis during DDC-induced liver injury relative to wild-type controls

• at day 12 of DDC treatment, DDC-damaged livers display denser networks of fibronectin and concentrated laminin around portal tract regions relative to wild-type controls

• DDC-treated livers show a 27% increase in alpha-smooth muscle actin-positive areas and a 23% increase in Sirius red-stained collagen fibrils relative to wild-type controls

cellular

decreased hepatocyte proliferation ( J:221183 )

• after feeding a 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet for 12 days to induce liver injury, mice show a 40% decrease of Ki-67+ hepatocytes relative to similarly treated wild-type controls

Genotype
MGI:5763181

hm2

• Allelic Composition: Adamts7^{tm1a(KOMP)Wtsi}/Adamts7^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N

respiratory system

increased tidal volume ( J:230573 )

increased total lung capacity ( J:230573 )

abnormal vital capacity ( J:230573 )

• increased

decreased airway resistance ( J:230573 )

decreased lung compliance ( J:230573 )

increased respiration ( J:230573 )

• increased lung function

• however, no emphysema is detected

cellular

abnormal vascular endothelial cell migration ( J:230573 )

• repressed cell migration

decreased vascular endothelial cell proliferation ( J:230573 )

• impaired proliferation in vivo and in vitro

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:230573 )

N • after 15 weeks, mice fed a Western diet exhibit normal blood lipid levels

abnormal vascular wound healing ( J:230573 )

• following carotid artery wire-injury, mice exhibit increased re-endothelialization and ameliorated neointima formation compared with wild-type mice

increased oxygen consumption ( J:230573 )

♂ • in male mice

abnormal triglyceride level ( J:230573 )

• mild

behavior/neurological

decreased anxiety-related response ( J:230573 )

• in an open-field test

impaired coordination ( J:230573 )

♀ • reduced rotarod latency in female mice

cardiovascular system

abnormal vascular endothelial cell migration ( J:230573 )

• repressed cell migration

decreased vascular endothelial cell proliferation ( J:230573 )

• impaired proliferation in vivo and in vitro

abnormal vascular wound healing ( J:230573 )

• following carotid artery wire-injury, mice exhibit increased re-endothelialization and ameliorated neointima formation compared with wild-type mice

hematopoietic system

abnormal erythrocyte cell number ( J:230573 )

• mild