Phenotypes associated with this allele

• Allele Symbol: Sytl1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363391
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sytl1^tm1a(KOMP)Wtsi/Sytl1^tm1a(KOMP)Wtsi	B6JTyr;B6N-Sytl1^tm1a(KOMP)Wtsi/Wtsi	MGI:5781775
hm2	Sytl1^tm1a(KOMP)Wtsi/Sytl1^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5791069

Genotype
MGI:5781775

hm1

• Allelic Composition: Sytl1^{tm1a(KOMP)Wtsi}/Sytl1^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Sytl1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0084_1_C03

Data Sources

IMPC Data for Sytl1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased hematocrit ( J:175295 )

♂

IMPC - WTSI

decreased hemoglobin content ( J:175295 )

♂

IMPC - WTSI

Genotype
MGI:5791069

hm2

• Allelic Composition: Sytl1^{tm1a(KOMP)Wtsi}/Sytl1^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0084_1_C03

behavior/neurological

abnormal locomotor coordination ( J:213427 )

nervous system

meningitis ( J:213427 )

• lymphocytic meningitis

reproductive system

epididymis inflammation ( J:213427 )

• periepididymitis

hematopoietic system

increased mean platelet volume ( J:213427 )

decreased mature B cell number ( J:213427 )

increased regulatory T cell number ( J:213427 )

decreased T cell number ( J:213427 )

decreased CD4-positive, alpha-beta T cell number ( J:213427 )

decreased IgG2b level ( J:213427 )

homeostasis/metabolism

decreased circulating amylase level ( J:213427 )

immune system

decreased mature B cell number ( J:213427 )

increased regulatory T cell number ( J:213427 )

decreased T cell number ( J:213427 )

decreased CD4-positive, alpha-beta T cell number ( J:213427 )

decreased IgG2b level ( J:213427 )

meningitis ( J:213427 )

• lymphocytic meningitis

epididymis inflammation ( J:213427 )

• periepididymitis

limbs/digits/tail

caudal vertebral transformation ( J:213427 )

skeleton

vertebral transformation ( J:213427 )

caudal vertebral transformation ( J:213427 )