Phenotypes associated with this allele

• Allele Symbol: Reg3g^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363444
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Reg3g^tm1a(KOMP)Wtsi/Reg3g^tm1a(KOMP)Wtsi	C57BL/6N-Reg3g^tm1a(KOMP)Wtsi/Wtsi	MGI:5608414
hm2	Reg3g^tm1a(KOMP)Wtsi/Reg3g^tm1a(KOMP)Wtsi	C57BL/6-Reg3g^tm1a(KOMP)Wtsi	MGI:5828533

Genotype
MGI:5608414

hm1

• Allelic Composition: Reg3g^{tm1a(KOMP)Wtsi}/Reg3g^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Reg3g^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0309_2_D08

Data Sources

IMPC Data for Reg3g

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:211773 )

IMPC - WTSI

increased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - WTSI

increased circulating LDL cholesterol level ( J:211773 )

IMPC - WTSI

Genotype
MGI:5828533

hm2

• Allelic Composition: Reg3g^{tm1a(KOMP)Wtsi}/Reg3g^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6-Reg3g^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0309_2_D08

immune system

increased susceptibility to Orthomyxoviridae infection ( J:233979 )

• a low pathogenic A/Puerto Rico/8/1934 H1N1 (PR8M) virus-infected mice exhibit altered weight loss and recovery compared with wild-type mice

• however, mortality following infection is normal