About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc15a3tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4363498
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc15a3tm1a(KOMP)Wtsi/Slc15a3tm1a(KOMP)Wtsi C57BL/6N-Slc15a3tm1a(KOMP)Wtsi MGI:6110851


Genotype
MGI:6110851
hm1
Allelic
Composition		 Slc15a3tm1a(KOMP)Wtsi/Slc15a3tm1a(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Slc15a3tm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc15a3tm1a(KOMP)Wtsi mutation (3 available); any Slc15a3 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal myeloid dendritic cell morphology ( J:210445 )
• after LPS (lipopolysaccharide) treatment, fewer than 30% of bone marrow-derived dendritic cells (BMDCs) show tubular endo-lysosomes, vs 80% WT
• reduced expression of Il1b and Il6

immune system
abnormal myeloid dendritic cell morphology ( J:210445 )
• after LPS (lipopolysaccharide) treatment, fewer than 30% of bone marrow-derived dendritic cells (BMDCs) show tubular endo-lysosomes, vs 80% WT
• reduced expression of Il1b and Il6




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory