Phenotypes associated with this allele

• Allele Symbol: Kat14^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363521
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kat14^tm1a(KOMP)Wtsi/Kat14^tm1a(KOMP)Wtsi	B6JTyr;B6N-Kat14^tm1a(KOMP)Wtsi/Wtsi	MGI:5781601
hm2	Kat14^tm1a(KOMP)Wtsi/Kat14^tm1a(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790948
hm3	Kat14^tm1a(KOMP)Wtsi/Kat14^tm1a(KOMP)Wtsi	involves: C57BL/6N	MGI:4830889
ht4	Kat14^tm1a(KOMP)Wtsi/Kat14^+	D2.B6N-Kat14^tm1a(KOMP)Wtsi	MGI:5912192
cx5	Kat14^tm1a(KOMP)Wtsi/Ppcd1	D2.Cg-Kat14^tm1a(KOMP)Wtsi/Ppcd1	MGI:5912187

Genotype
MGI:5781601

hm1

• Allelic Composition: Kat14^{tm1a(KOMP)Wtsi}/Kat14^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Kat14^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0025_4_B07

Data Sources

IMPC Data for Kat14

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:175295 )

IMPC - WTSI

cardiovascular system

cornea vascularization ( J:165965 )

♀

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:165965 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:165965 )

♂

IMPC - WTSI

abnormal maxilla morphology ( J:165965 )

♂

IMPC - WTSI

growth/size/body

abnormal tooth morphology ( J:165965 )

♂

IMPC - WTSI

decreased lean body mass ( J:165965 )

IMPC - WTSI

decreased body weight ( J:165965 )

IMPC - WTSI

decreased body length ( J:165965 )

IMPC - WTSI

hematopoietic system

decreased hemoglobin content ( J:165965 )

♀

IMPC - WTSI

pigmentation

abnormal eye pigmentation ( J:175295 )

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:165965 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:165965 )

♂

IMPC - WTSI

abnormal maxilla morphology ( J:165965 )

♂

IMPC - WTSI

increased sacral vertebrae number ( J:165965 )

♀

IMPC - WTSI

decreased bone mineral content ( J:165965 )

IMPC - WTSI

vision/eye

abnormal eye morphology ( J:165965 )

IMPC - WTSI

abnormal eye pigmentation ( J:175295 )

IMPC - WTSI

abnormal iris morphology ( J:165965 )

♂

IMPC - WTSI

abnormal cornea morphology ( J:165965 )

♀

IMPC - WTSI

cornea vascularization ( J:165965 )

♀

IMPC - WTSI

cornea opacity ( J:165965 )

IMPC - WTSI

abnormal eye size ( J:175295 )

♂

IMPC - WTSI

abnormal eyelid aperture ( J:165965 )

♂

IMPC - WTSI

eyelids fail to open ( J:165965 )

♂

IMPC - WTSI

Genotype
MGI:5790948

hm2

• Allelic Composition: Kat14^{tm1a(KOMP)Wtsi}/Kat14^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0025_4_B07

cardiovascular system

cornea vascularization ( J:213427 )

craniofacial

abnormal cranium morphology ( J:213427 )

abnormal tooth morphology ( J:213427 )

abnormal maxilla morphology ( J:213427 )

abnormal zygomatic bone morphology ( J:213427 )

growth/size/body

abnormal tooth morphology ( J:213427 )

decreased lean body mass ( J:213427 )

decreased body length ( J:213427 )

immune system

decreased susceptibility to bacterial infection ( J:213427 )

mortality/aging

lethality, incomplete penetrance ( J:213427 )

skeleton

abnormal cranium morphology ( J:213427 )

abnormal tooth morphology ( J:213427 )

abnormal maxilla morphology ( J:213427 )

abnormal zygomatic bone morphology ( J:213427 )

abnormal spine curvature ( J:213427 )

scoliosis ( J:213427 )

vertebral fusion ( J:213427 )

fusion of vertebral arches ( J:213427 )

vision/eye

abnormal cornea morphology ( J:213427 )

cornea vascularization ( J:213427 )

abnormal cornea stroma morphology ( J:213427 )

cornea opacity ( J:213427 )

abnormal eye development ( J:213427 )

abnormal eye size ( J:213427 )

eyelids fail to open ( J:213427 )

increased opacity of vitreous body ( J:213427 )

Genotype
MGI:4830889

hm3

• Allelic Composition: Kat14^{tm1a(KOMP)Wtsi}/Kat14^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0025_4_B07

mortality/aging

preweaning lethality, incomplete penetrance ( J:164007 , J:173680 )

vision/eye

cornea opacity ( J:164007 , J:173680 )

Genotype
MGI:5912192

ht4

• Allelic Composition: Kat14^{tm1a(KOMP)Wtsi}/Kat14⁺
• Genetic Background: D2.B6N-Kat14^{tm1a(KOMP)Wtsi}

vision/eye

vision/eye phenotype ( J:236024 )

N • unlike Ppcd1 heterozygotes, mice does not exhibit pan-cytokeratin immunoreactivity in the eye

Genotype
MGI:5912187

cx5

• Allelic Composition: Kat14^{tm1a(KOMP)Wtsi}/Ppcd1
• Genetic Background: D2.Cg-Kat14^{tm1a(KOMP)Wtsi}/Ppcd1

mortality/aging

preweaning lethality, complete penetrance ( J:236024 )

• no mice are present when survival is scored at weaning