Phenotypes associated with this allele

• Allele Symbol: Gmds^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363597
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gmds^tm1a(KOMP)Wtsi/Gmds^tm1a(KOMP)Wtsi	C57BL/6N-Gmds^tm1a(KOMP)Wtsi/Wtsi	MGI:5700905

Genotype
MGI:5700905

hm1

• Allelic Composition: Gmds^{tm1a(KOMP)Wtsi}/Gmds^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Gmds^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0034_5_H06

Data Sources

IMPC Data for Gmds

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

IMPC - WTSI

behavior/neurological

increased grip strength ( J:211773 )

♀

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:211773 )

♀

IMPC - WTSI

abnormal snout morphology ( J:211773 )

IMPC - WTSI

growth/size/body

abnormal snout morphology ( J:211773 )

IMPC - WTSI

decreased lean body mass ( J:211773 )

IMPC - WTSI

decreased body length ( J:211773 )

IMPC - WTSI

hematopoietic system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

decreased erythrocyte cell number ( J:211773 )

♀

IMPC - WTSI

decreased hematocrit ( J:211773 )

♀

IMPC - WTSI

decreased hemoglobin content ( J:211773 )

♀

IMPC - WTSI

decreased dendritic cell number ( J:211773 )

IMPC - WTSI

decreased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased mature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased macrophage cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased neutrophil cell number ( J:211773 )

IMPC - WTSI

increased immature NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased NK T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating iron level ( J:211773 )

♀

IMPC - WTSI

decreased circulating magnesium level ( J:211773 )

IMPC - WTSI

immune system

decreased transitional stage T2 B cell number ( J:211773 )

IMPC - WTSI

decreased dendritic cell number ( J:211773 )

IMPC - WTSI

decreased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased NK cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased mature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive mature NK cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, naive alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased KLRG1+ CD8 alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased T-helper cell number ( J:211773 )

IMPC - WTSI

decreased regulatory T cell number ( J:211773 )

IMPC - WTSI

decreased macrophage cell number ( J:211773 )

IMPC - WTSI

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

increased granulocyte number ( J:211773 )

IMPC - WTSI

increased neutrophil cell number ( J:211773 )

IMPC - WTSI

increased immature NK cell number ( J:211773 )

IMPC - WTSI

increased memory-marker NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased NK T cell number ( J:211773 )

IMPC - WTSI

increased CD4-negative NK T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:211773 )

♀

IMPC - WTSI

abnormal bone structure ( J:211773 )

♀

IMPC - WTSI

decreased bone mineral content ( J:211773 )

IMPC - WTSI