All Phenotypes Pear1<tm1a(KOMP)Wtsi> MGI Mouse

hematopoietic system

decreased platelet aggregation ( J:237835 )

• in vitro platelet aggregation in response to a low concentration of dextran sulfate 500 k (DxS, 0.25 nM) is impaired, resulting in rapid disintegration of the formed platelet aggregate

• Akt phosphorylation is reduced during DxS-induced aggregation (5 nM at 30% aggregation) or 5 uM adenosine diphosphate (ADP)-induced aggregation (at 6 min) relative to that in wild-type platelets, whereas Akt phosphorylation during collagen-induced aggregation (1 ug/ml at 30% aggregation) is normal

• however, collagen-, PAR4 activating peptide (AYPGK)-, and ADP-induced aggregation curves are normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:237835 )

N	• in vitro, clot retraction induced by adding human alpha-thrombin to platelet rich plasma is similar to that in wild-type platelets • in vivo, mice show normal tail vein bleeding time and normal thrombus formation in a ferric chloride-induced mesenteric thrombosis model

decreased platelet aggregation ( J:237835 )

• in vitro platelet aggregation in response to a low concentration of dextran sulfate 500 k (DxS, 0.25 nM) is impaired, resulting in rapid disintegration of the formed platelet aggregate

• however, collagen-, PAR4 activating peptide (AYPGK)-, and ADP-induced aggregation curves are normal

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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