Phenotypes associated with this allele

• Allele Symbol: Aldh18a1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363671
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aldh18a1^tm1a(KOMP)Wtsi/Aldh18a1^tm1a(KOMP)Wtsi	C57BL/6N-Aldh18a1^tm1a(KOMP)Wtsi/Wtsi	MGI:6261833
ht2	Aldh18a1^tm1a(KOMP)Wtsi/Aldh18a1^+	C57BL/6N-Aldh18a1^tm1a(KOMP)Wtsi/Wtsi	MGI:6272787

Genotype
MGI:6261833

hm1

• Allelic Composition: Aldh18a1^{tm1a(KOMP)Wtsi}/Aldh18a1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Aldh18a1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0071_1_D03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:232539 )

• homozygotes are not viable at P14

Genotype
MGI:6272787

ht2

• Allelic Composition: Aldh18a1^{tm1a(KOMP)Wtsi}/Aldh18a1⁺
• Genetic Background: C57BL/6N-Aldh18a1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0071_1_D03

integument

abnormal hypodermis fat layer morphology ( J:232539 )

♀ • at necropsy (16.1 weeks of age), mice fed a high-fat diet show mild, multifocal mixed inflammatory cell infiltration with mild fibrosis and distortion of adipocytes in the hypodermal fat layer

skin inflammation ( J:232539 )

♀ • mild, multifocal mixed inflammatory cell infiltration in the hypodermal fat layer

skin fibrosis ( J:232539 )

♀ • mild fibrosis in the hypodermal fat layer

adipose tissue

abnormal hypodermis fat layer morphology ( J:232539 )

♀ • at necropsy (16.1 weeks of age), mice fed a high-fat diet show mild, multifocal mixed inflammatory cell infiltration with mild fibrosis and distortion of adipocytes in the hypodermal fat layer

immune system

skin inflammation ( J:232539 )

♀ • mild, multifocal mixed inflammatory cell infiltration in the hypodermal fat layer