Phenotypes associated with this allele

• Allele Symbol: Cyp4b1^{tm1e(KOMP)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363698
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp4b1^tm1e(KOMP)Wtsi/Cyp4b1^tm1e(KOMP)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5560803

Genotype
MGI:5560803

hm1

• Allelic Composition: Cyp4b1^{tm1e(KOMP)Wtsi}/Cyp4b1^{tm1e(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0078_3_G01

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:207585 )

• male mice exhibit decreased microsomal 4-ipomeanol (IPO) activation in the kidney compared with wild-type mice

• female and male mice exhibit decreased microsomal IPO activation in the lung compared with wild-type mice

• IPO-treated mice do not develop lung lesions or renal toxicity unlike wild-type mice

• however, activation rates in the liver are normal