Analysis Tools|
Allele Symbol Allele Name Allele ID |
Slu7tm1a(KOMP)Wtsi targeted mutation 1a, Wellcome Trust Sanger Institute MGI:4363740 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - WTSI
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IMPC - WTSI
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after acute acetaminophen (APAP)-induced liver injury, mice show significantly lower serum APAP-glucuronide conjugate levels, suggesting a lower capacity for nontoxic APAP metabolism
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• mice exhibit decreased hepatic glycogen storage under both fasting and feeding conditions
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• mice exhibit insulin resistance, as indicated by impaired phosphorylation of glycogen synthase kinase 3 in the liver
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• after chronic CCl4-induced liver injury, mice show exacerbated liver damage with more bridging fibrosis, increased Col1a1 mRNA expression and activated (alpha-smooth muscle actin [alphaSMA]-positive) hepatic stellate cells (HSCs), and higher serum alanine aminotransferase (ALT) levels than wild-type controls
• after acute APAP-induced liver injury, mice show more parenchymal liver damage and higher serum levels of ALT, aspartate aminotransferase (AST), and lactate dehydrogenase, than wild-type controls
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• mice exhibit decreased hepatic glycogen storage under both fasting and feeding conditions
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• after chronic CCl4-induced liver injury, mice show an exacerbated promoter switch from P1-driven to P2-driven Hnf4a (hepatic nuclear factor 4, alpha) expression, with greater downregulation of Hnf4a P1 mRNA expression and HNF4alpha1 protein isoform expression and a more robust induction of Hnf4a P2 mRNA and protein isoforms than wild-type controls
• chronically CCl4-injured livers show higher Cyp2e1 mRNA levels, increased DNA damage, and higher accumulation of IgG, CYP2E1, and nitrosylated protein (3-nitrotyrosine) levels than CCl4-injured wild-type livers, consistent with aggravated liver damage and hepatic dedifferentiation
• after acute APAP-induced liver injury, mRNA expression of Hnf4a P1 isoforms is reduced at 6h while HNF4alpha1 protein isoform expression is depleted at 12 h after APAP treatment; these responses are paralleled by decreased protein levels of USP10 and G3BP1, increased expression of CYP2E1, and enhanced protein nitration, ROS production, heme-oxygenase-1 expression, and TP53 stabilization
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• mice exhibit significantly higher levels of reactive oxygen species (ROS) in the liver
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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