Phenotypes associated with this allele

• Allele Symbol: Tnnt3^{tm2a(KOMP)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4363809
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnnt3^tm2a(KOMP)Wtsi/Tnnt3^tm2a(KOMP)Wtsi	involves: C57BL/6N	MGI:5532748
ht2	Tnnt3^tm2a(KOMP)Wtsi/Tnnt3^+	involves: C57BL/6N	MGI:5532747

Genotype
MGI:5532748

hm1

• Allelic Composition: Tnnt3^{tm2a(KOMP)Wtsi}/Tnnt3^{tm2a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0084_2_G03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased size of Tnnt3^{tm2a(KOMP)Wtsi}/Tnnt3^{tm2a(KOMP)Wtsi} and Tnnt3^{tm2a(KOMP)Wtsi}/Tnnt3⁺ fetuses

mortality/aging

neonatal lethality, complete penetrance ( J:204474 )

• mice die shortly after birth

cardiovascular system

kidney hemorrhage ( J:204474 )

liver hemorrhage ( J:204474 )

growth/size/body

decreased fetal size ( J:204474 )

• at E18.5

muscle

thin diaphragm muscle ( J:204474 )

liver/biliary system

liver hemorrhage ( J:204474 )

renal/urinary system

kidney hemorrhage ( J:204474 )

Genotype
MGI:5532747

ht2

• Allelic Composition: Tnnt3^{tm2a(KOMP)Wtsi}/Tnnt3⁺
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0084_2_G03

Small size of the Tnnt3^{tm2a(KOMP)Wtsi}/Tnnt3⁺ mice

growth/size/body

decreased body size ( J:204474 )

• at 2 months

decreased body weight ( J:204474 )

• from 3 to 9 weeks

postnatal growth retardation ( J:204474 )

decreased fetal size ( J:204474 )

• at E18.5

skeleton

skeleton phenotype ( J:204474 )

N • mice exhibit normal joint development, mineralization and matrix composition

decreased long bone epiphyseal plate size ( J:204474 )

• at E18.5

abnormal bone mineralization ( J:204474 )

• increased, especially in the ankle, tail, elbow, spine and skull

limbs/digits/tail

short limbs ( J:204474 )

• very modest