About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ankle1tm1(KOMP)Wtsi
targeted mutation 1, Wellcome Trust Sanger Institute
MGI:4363814
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi C57BL/6N-Ankle1tm1(KOMP)Wtsi/Nju MGI:6261861
hm2
 		Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi involves: C57BL/6J * C57BL/6N MGI:5827620


Genotype
MGI:6261861
hm1
Allelic
Composition		 Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Ankle1tm1(KOMP)Wtsi/Nju
Cell Lines EPD0323_2_B12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankle1tm1(KOMP)Wtsi mutation (0 available); any Ankle1 mutation (27 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

integument

pigmentation




Genotype
MGI:5827620
hm2
Allelic
Composition		 Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Cell Lines EPD0323_2_B12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankle1tm1(KOMP)Wtsi mutation (0 available); any Ankle1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:235782 )
• heterozygous matings yield homozygotes at a reduced birth Mendelian ratio (14% vs expected 25%)
• however, born homozygotes exhibit no obvious defects, gain weight, and have a normal lifespan




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory