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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ankle1tm1(KOMP)Wtsi
targeted mutation 1, Wellcome Trust Sanger Institute
MGI:4363814
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi C57BL/6N-Ankle1tm1(KOMP)Wtsi/Nju MGI:6261861
hm2
 		Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi involves: C57BL/6J * C57BL/6N MGI:5827620


Genotype
MGI:6261861
hm1
Allelic
Composition		 Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi
Genetic
Background		 C57BL/6N-Ankle1tm1(KOMP)Wtsi/Nju
Cell Lines EPD0323_2_B12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankle1tm1(KOMP)Wtsi mutation (0 available); any Ankle1 mutation (27 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

integument

pigmentation




Genotype
MGI:5827620
hm2
Allelic
Composition		 Ankle1tm1(KOMP)Wtsi/Ankle1tm1(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6J * C57BL/6N
Cell Lines EPD0323_2_B12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ankle1tm1(KOMP)Wtsi mutation (0 available); any Ankle1 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:235782 )
• heterozygous matings yield homozygotes at a reduced birth Mendelian ratio (14% vs expected 25%)
• however, born homozygotes exhibit no obvious defects, gain weight, and have a normal lifespan




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory