Analysis Tools
mortality/aging
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• in response to S. enterica serovar Typhimurium and Citrobacter rodentium challenges
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homeostasis/metabolism
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• decreased high density lipoprotein
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• at least 20-fold reduction in blood plasma levels
• mice with heterozygous dams exhibit variable reductions
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immune system
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• of CD3+ and CD4+ T cells in the blood, but not spleen, of S. Typhimurium-infected mice
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• in the blood, but not spleen, of S. Typhimurium-infected mice
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• mice challenged with C. rodentium exhibit more severe epithelial inflammatory cell infiltration with crypt abscesses containing neutrophils and intraepithelial lymphocytes; increased submucosa inflammation and inflammatory clusters around the hepatic portal triad with occasional thrombus; elevated bacterial counts in the cecum, colon, spleen and liver; and increased mortality compared with wild-type mice
• mice challenged with S. Typhimurium exhibit increased damage with sizable areas of necrosis and regions of foamy fatty acid hepatocytes, extramedullary hematopoiesis with scattered large areas of necrosis with foci of macrophages in the red pulp compacting the white pulp, increased CD3+ and CD4+ T cells, and mortality compared with wild-type mice
• however, supplementation with vitamin B12 reverses S. Typhimurium susceptibility
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• in response to S. enterica serovar Typhimurium and Citrobacter rodentium challenges
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growth/size/body
cellular
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• mice with heterozygous dams exhibit normal blood chemistry, body size and body weight
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liver/biliary system
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• enlarge nuclei and abnormal mitotic figures
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hematopoietic system
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• in the spleen of S. Typhimurium-infected mice
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• hyperlobulated with hypersegmented nuclei in the spleen
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• of CD3+ and CD4+ T cells in the blood, but not spleen, of S. Typhimurium-infected mice
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• in the blood, but not spleen, of S. Typhimurium-infected mice
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