Phenotypes associated with this allele

• Allele Symbol: Kmo^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364232
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmo^tm1a(KOMP)Wtsi/Kmo^tm1a(KOMP)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5906143

Genotype
MGI:5906143

hm1

• Allelic Composition: Kmo^{tm1a(KOMP)Wtsi}/Kmo^{tm1a(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased exploration in new environment ( J:240498 )

• increased spontaneous alteration in LPS-treated mice during the Y-maze test compared with untreated mice and similarly treated wild-type mice

behavioral despair ( J:240498 )

• in a tail suspension test, mice treated with LPS exhibit increased duration of immobility compared with wild-type mice

• however, LPS-treated mice exhibit normal suppression of sucrose preference

increased thigmotaxis ( J:240498 )

• in LPS-treated mice compared with wild-type mice

• however, distance traveled in an open field is normal

homeostasis/metabolism

abnormal amino acid metabolism ( J:240498 )

• increased kynurenine levels in the brain of untreated and LPS-treated mice

• increased kynurenic acid in the brains of untreated mice

• decreased serum kynurenic acid in LPS-treated mice

• LPS treatment fails to increase 3-hydroxykynurenine serum levels