Phenotypes associated with this allele

• Allele Symbol: Gys2^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364592
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gys2^tm1a(KOMP)Wtsi/Gys2^tm1a(KOMP)Wtsi	B6J.B6N-Gys2^tm1a(KOMP)Wtsi	MGI:5568697
hm2	Gys2^tm1a(KOMP)Wtsi/Gys2^tm1a(KOMP)Wtsi	B6JTyr;B6N-Gys2^tm1a(KOMP)Wtsi/Wtsi	MGI:5781635
ht3	Gys2^tm1a(KOMP)Wtsi/Gys2^+	B6J.B6N-Gys2^tm1a(KOMP)Wtsi	MGI:5568695

Genotype
MGI:5568697

hm1

• Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi}
• Genetic Background: B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0086_2_F11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased liver glycogen level ( J:208923 )

• hepatocytes contain only a trace of glycogen

liver/biliary system

decreased liver glycogen level ( J:208923 )

• hepatocytes contain only a trace of glycogen

Genotype
MGI:5781635

hm2

• Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Gys2^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0086_2_F11

Data Sources

IMPC Data for Gys2

homeostasis/metabolism

decreased circulating glucose level ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

decreased circulating glycerol level ( J:175295 )

♀

IMPC - WTSI

increased circulating calcium level ( J:165965 )

IMPC - WTSI

increased circulating sodium level ( J:165965 )

IMPC - WTSI

increased circulating total protein level ( J:165965 )

IMPC - WTSI

increased circulating chloride level ( J:165965 )

IMPC - WTSI

integument

abnormal vibrissa morphology ( J:175295 )

♀

IMPC - WTSI

growth/size/body

decreased body weight ( J:165965 )

IMPC - WTSI

Genotype
MGI:5568695

ht3

• Allelic Composition: Gys2^{tm1a(KOMP)Wtsi}/Gys2⁺
• Genetic Background: B6J.B6N-Gys2^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0086_2_F11

liver/biliary system

liver/biliary system phenotype ( J:208923 )

N • mice exhibit normal blood glucose and liver glycogen levels after glucose injection