Phenotypes associated with this allele

• Allele Symbol: Atxn7l3^{tm1(KOMP)Wtsi}
• Allele Name: targeted mutation 1, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364787
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Atxn7l3^tm1(KOMP)Wtsi/Atxn7l3^tm1(KOMP)Wtsi	involves: C57BL/6N	MGI:5805405

Genotype
MGI:5805405

hm1

• Allelic Composition: Atxn7l3^{tm1(KOMP)Wtsi}/Atxn7l3^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0321_4_E11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:213770 )

• Western blot analysis of acidic extracts from mutant mESCs revealed strikingly elevated H2B monoubiquitination (H2Bub) global levels relative to wild-type mESCs

• after 10 min of treatment with actinomycin D (an inhibitor of transcription elongation), H2Bub is almost undetectable in wild-type mESCs, whereas H2Bub global levels remain unaltered in mutant mESCs at all analyzed time points