Phenotypes associated with this allele

• Allele Symbol: Nf1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364806
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nf1^tm1a(KOMP)Wtsi/Nf1^tm1a(KOMP)Wtsi	B6JTyr;B6N-Nf1^tm1a(KOMP)Wtsi/Wtsi	MGI:6263009
ht2	Nf1^tm1a(KOMP)Wtsi/Nf1^+	B6Dnk;B6Brd;B6N-Tyr^c-Brd Nf1^tm1a(KOMP)Wtsi/Wtsi	MGI:6272791
ht3	Nf1^tm1a(KOMP)Wtsi/Nf1^+	B6JTyr;B6N-Nf1^tm1a(KOMP)Wtsi/Wtsi	MGI:5781682

Genotype
MGI:6263009

hm1

• Allelic Composition: Nf1^{tm1a(KOMP)Wtsi}/Nf1^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Nf1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0033_1_F12

Data Sources

IMPC Data for Nf1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:6272791

ht2

• Allelic Composition: Nf1^{tm1a(KOMP)Wtsi}/Nf1⁺
• Genetic Background: B6Dnk;B6Brd;B6N-Tyr^c-Brd Nf1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0033_1_F12

integument

abnormal hair cycle anagen phase ( J:232539 )

♀

Genotype
MGI:5781682

ht3

• Allelic Composition: Nf1^{tm1a(KOMP)Wtsi}/Nf1⁺
• Genetic Background: B6JTyr;B6N-Nf1^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0033_1_F12

Data Sources

IMPC Data for Nf1

homeostasis/metabolism

decreased circulating alanine transaminase level ( J:175295 )

IMPC - WTSI

decreased circulating aspartate transaminase level ( J:175295 )

IMPC - WTSI

decreased lactate dehydrogenase level ( J:175295 )

IMPC - WTSI

growth/size/body

increased body weight ( J:165965 )

♀

IMPC - WTSI