Phenotypes associated with this allele

• Allele Symbol: Cog2^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364810
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cog2^tm1a(KOMP)Wtsi/Cog2^tm1a(KOMP)Wtsi	B6JTyr;B6N-Cog2^tm1a(KOMP)Wtsi/Wtsi	MGI:6262183
ht2	Cog2^tm1a(KOMP)Wtsi/Cog2^+	B6JTyr;B6N-Cog2^tm1a(KOMP)Wtsi/Wtsi	MGI:5781598

Genotype
MGI:6262183

hm1

• Allelic Composition: Cog2^{tm1a(KOMP)Wtsi}/Cog2^{tm1a(KOMP)Wtsi}
• Genetic Background: B6JTyr;B6N-Cog2^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0064_1_A10

Data Sources

IMPC Data for Cog2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5781598

ht2

• Allelic Composition: Cog2^{tm1a(KOMP)Wtsi}/Cog2⁺
• Genetic Background: B6JTyr;B6N-Cog2^{tm1a(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0064_1_A10

Data Sources

IMPC Data for Cog2

growth/size/body

decreased body weight ( J:175295 )

♂

IMPC - WTSI

hematopoietic system

increased hematocrit ( J:175295 )

♀

IMPC - WTSI

homeostasis/metabolism

decreased circulating creatinine level ( J:175295 )

♂

IMPC - WTSI

increased circulating triglyceride level ( J:175295 )

♂

IMPC - WTSI

decreased circulating alanine transaminase level ( J:175295 )

♂

IMPC - WTSI

decreased circulating aspartate transaminase level ( J:175295 )

♂

IMPC - WTSI

decreased lactate dehydrogenase level ( J:175295 )

♂

IMPC - WTSI