Phenotypes associated with this allele

• Allele Symbol: Aldh1l1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4364886
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aldh1l1^tm1a(KOMP)Wtsi/Aldh1l1^tm1a(KOMP)Wtsi	C57BL/6-Aldh1l1^tm1a(KOMP)Wtsi	MGI:6377264

Genotype
MGI:6377264

hm1

• Allelic Composition: Aldh1l1^{tm1a(KOMP)Wtsi}/Aldh1l1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6-Aldh1l1^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0132_6_G09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal homeostasis ( J:280537 )

• mice show altered glycine metabolism due to folate deficiency

• 11-fold increase in formiminoglutamate, an intermediate in the folate-dependent histidine degradation pathway, in the liver

abnormal folic acid level ( J:280537 )

• mice show differences in the levels of two folate pools in the liver, with a decrase in 10-formyltetrahydrofolate and increase in tetrahydrofolate/5,10-methylenetetrahydroflate levels

• 1.2-fold and 1.4-fold decrease in total folate in the liver of males and females, respectively

• total folate is lower in the brain of males

• tissue folic acid and dihydrofolate are decreased more than 2-fold and 5-fold, respectively

• however, no changes in levels of folate in the pancreas or whole blood of males is seen

decreased glycine level ( J:280537 )

• decrease in glycine and glycine conjugates with fatty acids in the liver, indicating altered glycine metabolism

increased serine level ( J:280537 )

• elevation of serine in the liver