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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Igsf11tm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4364956
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Igsf11tm1a(KOMP)Wtsi/Igsf11tm1a(KOMP)Wtsi involves: C57BL/6N MGI:5897631


Genotype
MGI:5897631
hm1
Allelic
Composition		 Igsf11tm1a(KOMP)Wtsi/Igsf11tm1a(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6N
Cell Lines EPD0297_2_A07
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igsf11tm1a(KOMP)Wtsi mutation (1 available); any Igsf11 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:234439 )
N
• mice exhibit normal levels of immature AMPARs
decreased excitatory postsynaptic current amplitude ( J:234439 )
• decreased miniature EPSCs in dentate gyrus granule cells
• however, frequency is normal and mEPSC amplitude and frequency in hippocampal CA1 pyramidal neurons is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory