Phenotypes associated with this allele

• Allele Symbol: Tbrg1^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4365070
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbrg1^tm1a(KOMP)Wtsi/Tbrg1^tm1a(KOMP)Wtsi	C57BL/6N-Tbrg1^tm1a(KOMP)Wtsi	MGI:5751533
ht2	Tbrg1^tm1a(KOMP)Wtsi/Tbrg1^+	C57BL/6N-Tbrg1^tm1a(KOMP)Wtsi	MGI:5751534

Genotype
MGI:5751533

hm1

• Allelic Composition: Tbrg1^{tm1a(KOMP)Wtsi}/Tbrg1^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Tbrg1^{tm1a(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:225146 )

• more mice are produced than expected based on Mendelian ratios

neoplasm

increased tumor incidence ( J:225146 )

• 50% of 66 week old mice develop neoplastic lesion; including early B-cell lymphoma (2 mice), uterine hemangioma (1 mice), preputial gland cyst (1 mice), Harderian gland adenoma (1 mice) and lung adenoma (1 mice)

increased Harderian gland adenoma incidence ( J:225146 )

• in 1 mouse

increased lung adenoma incidence ( J:225146 )

• in 1 mouse

increased hemangioma incidence ( J:225146 )

• uterine hemangioma in 1 mouse

increased B cell derived lymphoma incidence ( J:225146 )

• in 2 of 12 mice

hematopoietic system

hematopoietic system phenotype ( J:225146 )

N • mice exhibit normal numbers of pro/pre, transitional and follicular B cells

enlarged spleen ( J:225146 )

increased marginal zone B cell number ( J:225146 )

increased spleen white pulp amount ( J:225146 )

• reactive hyperplasia with loss of architecture

endocrine/exocrine glands

abnormal preputial gland morphology ( J:225146 )

• preputial gland cyst in 1 mouse

increased Harderian gland adenoma incidence ( J:225146 )

• in 1 mouse

immune system

enlarged spleen ( J:225146 )

increased marginal zone B cell number ( J:225146 )

increased spleen white pulp amount ( J:225146 )

• reactive hyperplasia with loss of architecture

integument

abnormal preputial gland morphology ( J:225146 )

• preputial gland cyst in 1 mouse

reproductive system

abnormal preputial gland morphology ( J:225146 )

• preputial gland cyst in 1 mouse

growth/size/body

enlarged spleen ( J:225146 )

respiratory system

increased lung adenoma incidence ( J:225146 )

• in 1 mouse

Genotype
MGI:5751534

ht2

• Allelic Composition: Tbrg1^{tm1a(KOMP)Wtsi}/Tbrg1⁺
• Genetic Background: C57BL/6N-Tbrg1^{tm1a(KOMP)Wtsi}

mortality/aging

abnormal survival ( J:225146 )

• more mice are produced than expected based on Mendelian ratios