Phenotypes associated with this allele

• Allele Symbol: Vangl1^{tm1e(KOMP)Wtsi}
• Allele Name: targeted mutation 1e, Wellcome Trust Sanger Institute
• Allele ID: MGI:4365105
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vangl1^tm1e(KOMP)Wtsi/Vangl1^tm1e(KOMP)Wtsi	C57BL/6N-Vangl1^tm1e(KOMP)Wtsi/Wtsi	MGI:6263848
ht2	Vangl1^tm1e(KOMP)Wtsi/Vangl1^+	C57BL/6N-Vangl1^tm1e(KOMP)Wtsi/Wtsi	MGI:5781792

Genotype
MGI:6263848

hm1

• Allelic Composition: Vangl1^{tm1e(KOMP)Wtsi}/Vangl1^{tm1e(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Vangl1^{tm1e(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0164_3_G07

Data Sources

IMPC Data for Vangl1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

greasy coat ( J:232539 )

increased foot pad pigmentation ( J:232539 )

♂ • 3 of 4 male homozygotes that survive to adulthood exhibit dark paw pads

limbs/digits/tail

abnormal foot pad morphology ( J:232539 )

♂

increased foot pad pigmentation ( J:232539 )

♂ • 3 of 4 male homozygotes that survive to adulthood exhibit dark paw pads

mortality/aging

preweaning lethality, incomplete penetrance ( J:232539 , J:211773 )

MGI

• very few homozygotes survive to weaning; only 2% of live births are observed from heterozygous intercrosses (J:232539)

IMPC - WTSI (J:211773)

pigmentation

increased foot pad pigmentation ( J:232539 )

♂ • 3 of 4 male homozygotes that survive to adulthood exhibit dark paw pads

Genotype
MGI:5781792

ht2

• Allelic Composition: Vangl1^{tm1e(KOMP)Wtsi}/Vangl1⁺
• Genetic Background: C57BL/6N-Vangl1^{tm1e(KOMP)Wtsi}/Wtsi
• Cell Lines: EPD0164_3_G07

Data Sources

IMPC Data for Vangl1

hematopoietic system

increased mean corpuscular hemoglobin ( J:175295 )

IMPC - WTSI

skeleton

increased bone mineral content ( J:175295 )

IMPC - WTSI