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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Themistm1Hasu
targeted mutation 1, Harumi Suzuki
MGI:4365409
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Themistm1Hasu/Themistm1Hasu involves: C57BL/6 * CBA MGI:4365447
ht2
 		Themistm1Hasu/Themis+ involves: C57BL/6 * CBA MGI:4365448


Genotype
MGI:4365447
hm1
Allelic
Composition		 Themistm1Hasu/Themistm1Hasu
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themistm1Hasu mutation (0 available); any Themis mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell proliferation ( J:153235 )
• peripheral T cells proliferation is increased in the absence of stimulation due to homeostatic expansion compared to in wild-type mice
abnormal T cell differentiation ( J:153235 )
• differentiation of double positive T cells in the thymus is inhibited compared to in wild-type mice
• however, mice exhibit normal beta selection, negative selection, peripheral activation, and homeostatic proliferation
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• CD4+ T cells are decreased in the thymus as early as in neonates but mildly in the periphery compared to in wild-type mice
• CD4+ T cells are decreased in the spleen and lymph nodes compared to in wild-type mice
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• CD8+ T cells are decreased in the thymus as early as in neonates but mildly in the periphery compared to in wild-type mice
• CD8+ T cells are decreased in the spleen and lymph nodes compared to in wild-type mice
increased memory T cell number ( J:153235 )
• mice exhibit an increase in the number of memory/activated CD4+ T cells compared with wild-type mice

hematopoietic system
increased T cell proliferation ( J:153235 )
• peripheral T cells proliferation is increased in the absence of stimulation due to homeostatic expansion compared to in wild-type mice
abnormal T cell differentiation ( J:153235 )
• differentiation of double positive T cells in the thymus is inhibited compared to in wild-type mice
• however, mice exhibit normal beta selection, negative selection, peripheral activation, and homeostatic proliferation
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• CD4+ T cells are decreased in the thymus as early as in neonates but mildly in the periphery compared to in wild-type mice
• CD4+ T cells are decreased in the spleen and lymph nodes compared to in wild-type mice
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• CD8+ T cells are decreased in the thymus as early as in neonates but mildly in the periphery compared to in wild-type mice
• CD8+ T cells are decreased in the spleen and lymph nodes compared to in wild-type mice
increased memory T cell number ( J:153235 )
• mice exhibit an increase in the number of memory/activated CD4+ T cells compared with wild-type mice

endocrine/exocrine glands

cellular
increased T cell proliferation ( J:153235 )
• peripheral T cells proliferation is increased in the absence of stimulation due to homeostatic expansion compared to in wild-type mice




Genotype
MGI:4365448
ht2
Allelic
Composition		 Themistm1Hasu/Themis+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themistm1Hasu mutation (0 available); any Themis mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD4+ cells compared to in wild-type mice and homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD8+ cells compared to in wild-type mice and homozygotes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD4+ cells compared to in wild-type mice and homozygotes
decreased CD8-positive, alpha-beta T cell number ( J:153235 )
• mice exhibit an intermediate decrease in thymic CD8+ cells compared to in wild-type mice and homozygotes




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory