Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ptpn11tm1.1Wbm targeted mutation 1.1, Walter Birchmeier MGI:4365539 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following treatment with His-TAT-NLS-cre, Schwann cells exhibit severely blunted Nrg1-induced proliferation and blocked Nrg1-induced migration compared with similarly treated wild-type cells even in the presence of the Shp2 inhibitor PHPS1
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• myelination defects are more pronounced than in single conditional Ptpn11tm1.1Wbm homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show normal myelination at P15, however axons of peripheral nerves are hypermyelinated by P90
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the ventral but not dorsal roots
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• peripheral nerves are hypomyelinated with thinner myelin in axons with larger axon diameter
(J:153219)
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• in the saphenous nerve
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice die around E13.5
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• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit reduced axonal arborization compared to in wild-type mice
• however, incubation with wild-type Schwann cells restores axon outgrowth
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• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation unlike in wild-type mice
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• Ret+ enteric neural crest cells are reduced compared to in wild-type mice
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• at E11.5, BFABP+ Schwann cell precursors are reduced compared to in wild-type mice
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• at E12.5, Sox10+ Schwann cell precursors are not detected in peripheral nerves unlike in wild-type mice
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• at E13.5, Schwann cell nuclei in peripheral nerves are virtually absent unlike in wild-type mice
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• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation and reduced axonal arborization compared to in wild-type mice
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• at E12.5, lumbar dorsal root ganglia sensory neurons exhibit increased cell death compared to in wild-type mice
• numbers of sensory neurons in the dorsal root ganglia are strongly reduced compared to in wild-type mice
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• melanocytes are reduced in number compared to in wild-type mice
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• Ret+ enteric neural crest cells are reduced compared to in wild-type mice
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• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit reduced axonal arborization compared to in wild-type mice
• however, incubation with wild-type Schwann cells restores axon outgrowth
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• at E11.5, cutaneous, intercostal, and limb sensory neuron projections exhibit defasciculation unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show myelination defects similar to single conditional Ptpn11tm1.1Wbm homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• axons of peripheral nerves are hypermyelinated at P90
• however, mice show normal numbers of Schwann cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• disruption of entry into the myelination program of remaining Schwann cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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