Analysis Tools
mortality/aging
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• a slightly reduced (22% vs. 27%) Mendelian ratio homozygous mice were born
• time of death was not reported
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hematopoietic system
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• in mice with dermatitis
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• splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype
splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype
splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype
• mice treated with Oxazolone showed accumulation of T cells with an activated phenotype
• there is no apparent immune phenotype or other physical abnormalities present in naive unmanipulated homozygous mice
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immune system
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• in mice with dermatitis
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• splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype
splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype
splenic CD3+ T cells of homozygous mice had an increased frequency of T cells with an activated phenotype
• mice treated with Oxazolone showed accumulation of T cells with an activated phenotype
• there is no apparent immune phenotype or other physical abnormalities present in naive unmanipulated homozygous mice
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• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone
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• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone
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• in mice with dermatitis
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• development of systemic autoimmunity
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• mice with dermatitis developed antinuclear antibodies (ANAs), with specificity for DNA, and autoantibodies to several lupus-
associated autoantigens and other autoantigens
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• significantly higher contact hypersensitivity to low doses of the contact-sensitizing agent Oxazolone
significantly higher contact hypersensitivity to low doses of the contact-sensitizing agent Oxazolone
significantly higher contact hypersensitivity to low doses of the contact-sensitizing agent Oxazolone
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dermatitis
(
J:151775
)
|
• 25 wk after application of metal ear tags, >90% of homozygous mice had developed a very severe and progressive dermatitis emanating from the tagged ear, which did not occur in WT littermates
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homeostasis/metabolism
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• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone
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• production of high amounts of the proinflammatory cytokines IL-6, IL-12/IL-23p40, TNF-alpha, and IL-17 and IL-23R expression after application of Oxazolone
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• kidney pathology with substantiated mesangium and intraglomerular immunoglobulin depositions, as well as proteinuria
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renal/urinary system
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• kidney pathology with substantiated mesangium and intraglomerular immunoglobulin depositions, as well as proteinuria
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integument
dermatitis
(
J:151775
)
|
• 25 wk after application of metal ear tags, >90% of homozygous mice had developed a very severe and progressive dermatitis emanating from the tagged ear, which did not occur in WT littermates
|
growth/size/body
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• in mice with dermatitis
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