Analysis Tools
mortality/aging
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• about 40% of mice display severe respiratory distress and die within 15 min of birth
• the remaining 60% of mice die within 24 h of birth
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respiratory system
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• impaired differentiation of type II pneumocytes
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• decrease in saccular space at E18.5
• treatment with dexamethasone prior to birth restores saccular space but does not improve survival
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• cells contain abundant glycogen granules and have attenuated villi indicating that the cells retain an immature phenotype
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• at E18.5 lung weight is reduced by 25 - 40% and the lung weight to body weight ratio is significantly decreased
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• at E18.5 the number of proliferating cells is reduced by 60% compared to wild-type littermates
• decreases in cell proliferation are significant by E16.5
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atelectasis
(
J:153218
)
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• extensive and severe atelectasis is seen in mice that display respiratory distress
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• severe distress is seen in about 40% of neonates
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• about 40% of neonates die of acute respiratory failure within 15 min of birth
• lungs from these mice are not inflated with air
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homeostasis/metabolism
behavior/neurological
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• mice that survive more than 15 min. after birth display a reduced suckling reflex and lack milk in their stomachs
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• mice that survive more than 15 min. after birth fail to respond to pinching
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• mice that survive more than 15 min. after birth display uncoordinated movements
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carpoptosis
(
J:153218
)
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• seen in all mice
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• mice that survive more than 15 min. after birth display infirm vocalization
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skeleton
cardiovascular system
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• at E18.5 heart weight is reduced by 25 - 40% and the heart weight to body weight ratio is significantly decreased
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growth/size/body
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• decrease in body weight compared to wild-type littermates is detected from E14.5 onwards
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liver/biliary system
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• at E18.5 liver weight is reduced by 25 - 40% and the liver weight to body weight ratio is significantly decreased
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