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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp73tm1(cre)Agof
targeted mutation 1, Andre M Goffinet
MGI:4365581
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trp73tm1(cre)Agof/Trp73tm1(cre)Agof involves: 129S1/Sv * 129X1/SvJ MGI:4365608
cn2
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Trp73tm1(cre)Agof/Trp73+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365609
cn3
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365610
cn4
 		Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4365612


Genotype
MGI:4365608
hm1
Allelic
Composition		 Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased neuron apoptosis ( J:153209 )
• at E13.5, apoptotic Cajal-Retzius cells are detected in the cortical marginal zone and cortical hem; in the trigeminal ganglion, apoptosis is drastically increased compared to wild-type controls
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers
abnormal forebrain development ( J:153209 )
• from E12.5 onward, number of Cajal-Retzius cells in marginal zone, thalamic eminence, or choroid plexuses labeling for the deleted Trp73 isoform DeltaNp73 progressively decreases compared to controls, becoming significant after birth; at P0, Reelin-positive cells are reduced by 50%
abnormal choroid plexus morphology ( J:153209 )
• choroid plexus is reduced in size at P0
abnormal hypothalamus morphology ( J:153209 )
• number of GnRH-positive neurons in preoptic area (generated initially in VNO) is dramatically reduced at P0

reproductive system
reduced fertility ( J:153209 )
• both males and females exhibit impaired fertility; this is particularly evident in females which generate only 2 or three litters

respiratory system
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers

craniofacial
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers

cellular
increased neuron apoptosis ( J:153209 )
• at E13.5, apoptotic Cajal-Retzius cells are detected in the cortical marginal zone and cortical hem; in the trigeminal ganglion, apoptosis is drastically increased compared to wild-type controls

growth/size/body
abnormal vomeronasal organ morphology ( J:153209 )
• in adults, vomeronasal organ (VNO) neurons and axons are significantly reduced in numbers




Genotype
MGI:4365609
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Trp73tm1(cre)Agof/Trp73+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced




Genotype
MGI:4365610
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells in the cortical marginal zone is reduced by 72% at P0




Genotype
MGI:4365612
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+
Relnrl/Reln+
Trp73tm1(cre)Agof/Trp73+
Wnt3atm1(cre)Eag/Wnt3a+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Riet mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Relnrl mutation (3 available); any Reln mutation (209 available)
Trp73tm1(cre)Agof mutation (0 available); any Trp73 mutation (46 available)
Wnt3atm1(cre)Eag mutation (0 available); any Wnt3a mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased Cajal-Retzius cell number ( J:153209 )
• number of Cajal-Retzius cells (CRc) in the cortical marginal zone is reduced by 84% at P0
• nearly all CRc in the hippocampal formation are ablated




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory