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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Capn10tm1Chev
targeted mutation 1, James M Cheverud
MGI:4365744
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Adip1LG/J/?
Capn10tm1Chev/Capn10+ 		(B6.129-Capn10tm1Chev x LG/J)F1 MGI:4365746
cx2
 		Adip1SM/J/?
Capn10tm1Chev/Capn10+ 		(B6.129-Capn10tm1Chev x SM/J)F1 MGI:4365747


Genotype
MGI:4365746
cx1
Allelic
Composition		 Adip1LG/J/?
Capn10tm1Chev/Capn10+
Genetic
Background		 (B6.129-Capn10tm1Chev x LG/J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adip1LG/J mutation (0 available); any Adip1 mutation (0 available)
Capn10tm1Chev mutation (0 available); any Capn10 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating glucose level ( J:153477 )
• compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased circulating leptin level ( J:153477 )
• 50% increased compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
decreased circulating cholesterol level ( J:153477 )
• compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
decreased circulating free fatty acids level ( J:153477 )
• compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
decreased circulating triglyceride level ( J:153477 )
• compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet

adipose tissue
increased gonadal fat pad weight ( J:153477 )
• 41% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased inguinal fat pad weight ( J:153477 )
• 19% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased mesenteric fat pad weight ( J:153477 )
• 41% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased renal fat pad weight ( J:153477 )
• 58% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased total fat pad weight ( J:153477 )
• when fed a high-fat diet, total fat pad weight is increased 37% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice
• reproductive, renal, mesenteric, and inguinal fat pads are increased 41%, 58%, 41%, and 19% , respectively, compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 mice when fed a high-fat diet

growth/size/body
increased heart weight ( J:153477 )
• 16% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased body weight ( J:153477 )
• 18% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased kidney weight ( J:153477 )
• 7% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased liver weight ( J:153477 )
• 34% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet
increased spleen weight ( J:153477 )
• 13% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet

cardiovascular system
increased heart weight ( J:153477 )
• 16% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet

hematopoietic system
increased spleen weight ( J:153477 )
• 13% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet

renal/urinary system
increased kidney weight ( J:153477 )
• 7% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet

liver/biliary system
increased liver weight ( J:153477 )
• 34% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet

immune system
increased spleen weight ( J:153477 )
• 13% compared to in (C57BL/6 x LG/J-Adip1LG/J)F1 control mice when fed a high-fat diet




Genotype
MGI:4365747
cx2
Allelic
Composition		 Adip1SM/J/?
Capn10tm1Chev/Capn10+
Genetic
Background		 (B6.129-Capn10tm1Chev x SM/J)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adip1SM/J mutation (0 available); any Adip1 mutation (0 available)
Capn10tm1Chev mutation (0 available); any Capn10 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased circulating glucose level ( J:153477 )
• 27% at the baseline and 26% to 40% throughout the 2-hour glucose tolerance test compared to in (C57BL/6 x SM/J-Adip1SM/J)F1 control mice when fed a high-fat diet
decreased circulating cholesterol level ( J:153477 )
• compared to in (C57BL/6 x SM/J-Adip1SM/J)F1 control mice when fed a high-fat diet
decreased circulating free fatty acids level ( J:153477 )
• in male mice compared to in (C57BL/6 x SM/J-Adip1SM/J)F1 control mice when fed a high-fat diet
decreased circulating triglyceride level ( J:153477 )
• in male mice compared to in (C57BL/6 x SM/J-Adip1SM/J)F1 control mice when fed a high-fat diet




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory