Phenotypes associated with this allele

• Allele Symbol: Osr2^tm5(cre)Jian
• Allele Name: targeted mutation 5, Rulang Jiang
• Allele ID: MGI:4365778
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Osr2^tm5(cre)Jian/Osr2^+	involves: 129X1/SvJ	MGI:4365781
cn2	Osr2^tm5(cre)Jian/Osr2^+ Tg(CAG-Nog)1Ych/0	Not Specified	MGI:7345566

Genotype
MGI:4365781

cn1

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Osr2^tm5(cre)Jian/Osr2⁺
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:153554 )

craniofacial

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

cleft palate ( J:153554 )

embryo

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

digestive/alimentary system

cleft palate ( J:153554 )

growth/size/body

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

cleft palate ( J:153554 )

skeleton

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

Genotype
MGI:7345566

cn2

• Allelic Composition: Osr2^tm5(cre)Jian/Osr2⁺; Tg(CAG-Nog)1Ych/0
• Genetic Background: Not Specified

craniofacial

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

muscle

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

abnormal superior pharyngeal constrictor muscle morphology ( J:310908 )

• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers

digestive/alimentary system

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

growth/size/body

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

respiratory system

abnormal superior pharyngeal constrictor muscle morphology ( J:310908 )

• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers