All Phenotypes Otx2<tm9Asim> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Otx2^tm9Asim
targeted mutation 9, Antonio Simeone
MGI:4365828

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Otx2^tm9Asim/Otx2^tm9Asim	involves: 129P2/OlaHsd	MGI:4365907
ht2	Otx2^tm9Asim/Otx2^tm10Asim	involves: 129P2/OlaHsd	MGI:4365906
ht3	Otx2^tm9Asim/Otx2^tm11Asim	involves: 129P2/OlaHsd	MGI:4365908

Allelic Composition	Otx2^tm9Asim/Otx2^tm9Asim
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm9Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:153562 )

• at E9.5, mice exhibit loss of forebrain markers

abnormal midbrain development ( J:153562 )

• at E9.5, mice exhibit loss of midbrain markers

exencephaly ( J:153562 )

• in 60% of mice

craniofacial

abnormal craniofacial morphology ( J:153562 )

• mice exhibit severe head abnormalities

growth/size/body

acephaly ( J:153562 )

• 40% of mice exhibit a headless phenotype

Allelic Composition	Otx2^tm9Asim/Otx2^tm10Asim
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm10Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2^tm9Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

embryo phenotype ( J:153562 )

N	• at E9.5, mice exhibit no abnormalities

Allelic Composition	Otx2^tm9Asim/Otx2^tm11Asim
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2^tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2^tm9Asim mutation (1 available); any Otx2 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal forebrain development ( J:153562 )

• at E9.5, mice exhibit loss of forebrain markers

abnormal midbrain development ( J:153562 )

• at E9.5, mice exhibit loss of midbrain markers

growth/size/body

acephaly ( J:153562 )

• in almost all mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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