About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm11Asim
targeted mutation 11, Antonio Simeone
MGI:4365830
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otx2tm11Asim/Otx2tm11Asim involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5573222
ht2
 		Otx2tm11Asim/Otx2+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5573223
ht3
 		Otx2tm9Asim/Otx2tm11Asim involves: 129P2/OlaHsd MGI:4365908
ht4
 		Otx2tm10Asim/Otx2tm11Asim involves: 129P2/OlaHsd MGI:4365910
ht5
 		Otx2tm12.1Asim/Otx2tm11Asim involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5573224
cn6
 		Otx2tm6Asim/Otx2tm11Asim
Slc6a3tm1.1(cre)Bkmn/Slc6a3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4887467


Genotype
MGI:5573222
hm1
Allelic
Composition		 Otx2tm11Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5573223
ht2
Allelic
Composition		 Otx2tm11Asim/Otx2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:207121 )
N
• normal Mueller glia and amacrine cell numbers at P30
decreased retina cone cell number ( J:207121 )
• reduced red/green sensitive cones in most of the retina in mice older than P300
abnormal retina bipolar cell morphology ( J:207121 )
• reduced numbers at P30
abnormal retina horizontal cell morphology ( J:207121 )
• reduced numbers in the inner nuclear layer
thin retina inner nuclear layer ( J:207121 )
• at P14 and progressively worse at P30, P60 and P120
abnormal cone electrophysiology ( J:207121 )
• reduced photopic ERG amplitude at P30
abnormal rod electrophysiology ( J:207121 )
• reduced a-wave under scotopic conditions at P30 and P60
• increased a-wave and b-wave latency at P60 under scotopic conditions
• reduced b-wave under scotopic conditions at P30
decreased visual acuity ( J:207121 )
• mice exhibit reduced response in a visual acuity test

nervous system
decreased retina cone cell number ( J:207121 )
• reduced red/green sensitive cones in most of the retina in mice older than P300
abnormal retina bipolar cell morphology ( J:207121 )
• reduced numbers at P30
abnormal retina horizontal cell morphology ( J:207121 )
• reduced numbers in the inner nuclear layer




Genotype
MGI:4365908
ht3
Allelic
Composition		 Otx2tm9Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm9Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal forebrain development ( J:153562 )
• at E9.5, mice exhibit loss of forebrain markers
abnormal midbrain development ( J:153562 )
• at E9.5, mice exhibit loss of midbrain markers

growth/size/body
acephaly ( J:153562 )
• in almost all mice




Genotype
MGI:4365910
ht4
Allelic
Composition		 Otx2tm10Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm10Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:153562 )
• 70% of mice exhibit heavy abnormalities and reminiscent of Otx2 null embryos and 30% of mice exhibit less severe defects on the body and head

growth/size/body
abnormal head morphology ( J:153562 )




Genotype
MGI:5573224
ht5
Allelic
Composition		 Otx2tm12.1Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm12.1Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system

growth/size/body
abnormal head morphology ( J:207121 )
• truncated




Genotype
MGI:4887467
cn6
Allelic
Composition		 Otx2tm6Asim/Otx2tm11Asim
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm6Asim mutation (1 available); any Otx2 mutation (50 available)
Slc6a3tm1.1(cre)Bkmn mutation (3 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )
• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice
abnormal neuron differentiation ( J:166896 )
• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice

homeostasis/metabolism
increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )
• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice

cellular
increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )
• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice
abnormal neuron differentiation ( J:166896 )
• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory