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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Otx2tm11Asim
targeted mutation 11, Antonio Simeone
MGI:4365830
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Otx2tm11Asim/Otx2tm11Asim involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5573222
ht2
 		Otx2tm11Asim/Otx2+ involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5573223
ht3
 		Otx2tm9Asim/Otx2tm11Asim involves: 129P2/OlaHsd MGI:4365908
ht4
 		Otx2tm10Asim/Otx2tm11Asim involves: 129P2/OlaHsd MGI:4365910
ht5
 		Otx2tm12.1Asim/Otx2tm11Asim involves: 129P2/OlaHsd * C57BL/6 * DBA/2 MGI:5573224
cn6
 		Otx2tm6Asim/Otx2tm11Asim
Slc6a3tm1.1(cre)Bkmn/Slc6a3+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:4887467


Genotype
MGI:5573222
hm1
Allelic
Composition		 Otx2tm11Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5573223
ht2
Allelic
Composition		 Otx2tm11Asim/Otx2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:207121 )
N
• normal Mueller glia and amacrine cell numbers at P30
decreased retina cone cell number ( J:207121 )
• reduced red/green sensitive cones in most of the retina in mice older than P300
abnormal retina bipolar cell morphology ( J:207121 )
• reduced numbers at P30
abnormal retina horizontal cell morphology ( J:207121 )
• reduced numbers in the inner nuclear layer
thin retina inner nuclear layer ( J:207121 )
• at P14 and progressively worse at P30, P60 and P120
abnormal cone electrophysiology ( J:207121 )
• reduced photopic ERG amplitude at P30
abnormal rod electrophysiology ( J:207121 )
• reduced a-wave under scotopic conditions at P30 and P60
• increased a-wave and b-wave latency at P60 under scotopic conditions
• reduced b-wave under scotopic conditions at P30
decreased visual acuity ( J:207121 )
• mice exhibit reduced response in a visual acuity test

nervous system
decreased retina cone cell number ( J:207121 )
• reduced red/green sensitive cones in most of the retina in mice older than P300
abnormal retina bipolar cell morphology ( J:207121 )
• reduced numbers at P30
abnormal retina horizontal cell morphology ( J:207121 )
• reduced numbers in the inner nuclear layer




Genotype
MGI:4365908
ht3
Allelic
Composition		 Otx2tm9Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm9Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal forebrain development ( J:153562 )
• at E9.5, mice exhibit loss of forebrain markers
abnormal midbrain development ( J:153562 )
• at E9.5, mice exhibit loss of midbrain markers

growth/size/body
acephaly ( J:153562 )
• in almost all mice




Genotype
MGI:4365910
ht4
Allelic
Composition		 Otx2tm10Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm10Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:153562 )
• 70% of mice exhibit heavy abnormalities and reminiscent of Otx2 null embryos and 30% of mice exhibit less severe defects on the body and head

growth/size/body
abnormal head morphology ( J:153562 )




Genotype
MGI:5573224
ht5
Allelic
Composition		 Otx2tm12.1Asim/Otx2tm11Asim
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm12.1Asim mutation (1 available); any Otx2 mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

nervous system

growth/size/body
abnormal head morphology ( J:207121 )
• truncated




Genotype
MGI:4887467
cn6
Allelic
Composition		 Otx2tm6Asim/Otx2tm11Asim
Slc6a3tm1.1(cre)Bkmn/Slc6a3+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otx2tm11Asim mutation (1 available); any Otx2 mutation (50 available)
Otx2tm6Asim mutation (1 available); any Otx2 mutation (50 available)
Slc6a3tm1.1(cre)Bkmn mutation (3 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )
• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice
abnormal neuron differentiation ( J:166896 )
• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice

homeostasis/metabolism
increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )
• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice

cellular
increased susceptibility to dopaminergic neuron neurotoxicity ( J:166896 )
• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice
abnormal neuron differentiation ( J:166896 )
• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory