Phenotypes associated with this allele

• Allele Symbol: Gprasp1^tm1Ics
• Allele Name: targeted mutation 1, Mouse Clinical Institute
• Allele ID: MGI:4365990
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gprasp1^tm1Ics/Gprasp1^tm1Ics	involves: 129S2/SvPas * C57BL/6J	MGI:4365991

Genotype
MGI:4365991

hm1

• Allelic Composition: Gprasp1^tm1Ics/Gprasp1^tm1Ics
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:153526 )

♀N • mice exhibit normal spatial memory and anxiety-related behavior

impaired behavioral response to cocaine ( J:153526 )

♀ • following the first acute cocaine administration, mice fail to exhibit an increase in locomotor activity unlike similarly treated wild-type mice

♀ • successive injection of cocaine produce a delayed increase in locomotor enhancement compared with similarly treated wild-type mice

♀ • in a locomotor sensitization paradigm, cocaine-treated mice exhibit a greater reduction in vertical activity compared with similarly treated wild-type mice

♀ • mice exhibit an impairment in the acquisition of cocaine self-administration compared with similarly treated wild-type mice

decreased vertical activity ( J:153526 )

♀ • slightly