Phenotypes associated with this allele

• Allele Symbol: Tg(GATA5-cre)1Krc
• Allele Name: transgene insertion 1, Kenneth R Chien
• Allele ID: MGI:4366011
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tgfbr1^tm1Karl/Tgfbr1^tm1.1Karl Tg(GATA5-cre)1Krc/0	involves: 129	MGI:4836601
cn2	Wt1^tm1.1Ndha/Wt1^tm1Nhsn Tg(GATA5-cre)1Krc/0	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:4849369
cn3	Ppp3r1^tm2Grc/Ppp3r1^tm2Grc Tg(GATA5-cre)1Krc/0	involves: 129S6/SvEvTac	MGI:4366030

Genotype
MGI:4836601

cn1

• Allelic Composition: Tgfbr1^tm1Karl/Tgfbr1^tm1.1Karl; Tg(GATA5-cre)1Krc/0
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157922 )

• die after birth

respiratory system

abnormal lung development ( J:157922 )

• late lung development is blocked such that lungs appear more cellular and contain immature alveoli and reduced airspace in distal lungs at E18.5 compared to wild-type

• marker analysis indicates that bronchiolar epithelial progenitor cell differentiation is impaired, however alveolar epithelial cell differentiation appears normal

abnormal bronchiole epithelium morphology ( J:157922 )

• bronchiolar epithelial progenitor cell differentiation is impaired

decreased club cell number ( J:157922 )

• Clara cell numbers are reduced in E18.5 lungs

small lung ( J:157922 )

• lungs are smaller at E15.5

abnormal pulmonary alveolus morphology ( J:157922 )

• distal airways are composed of highly disorganized cells

dilated respiratory conducting tube ( J:157922 )

• enlarged airways in the lungs at E15.5

integument

abnormal skin development ( J:157922 )

• fail to develop ventral skin

Genotype
MGI:4849369

cn2

• Allelic Composition: Wt1^tm1.1Ndha/Wt1^tm1Nhsn; Tg(GATA5-cre)1Krc/0
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:166573 )

• mice die between E16.5 and E18.5 as a result of cardiovascular failure

cardiovascular system

abnormal heart right ventricle morphology ( J:166573 )

• some mice exhibit thinner free walls compared to in wild-type mice

abnormal cardiovascular system physiology ( J:166573 )

• mice die between E16.5 and E18.5 as a result of cardiovascular failure

hemopericardium ( J:166573 )

• mice exhibit pericardial hemorrhaging unlike wild-type mice

poor circulation ( J:166573 )

• at E16.5, mice exhibit an accumulation of blood in the systemic veins unlike in wild-type mice

homeostasis/metabolism

hemopericardium ( J:166573 )

• mice exhibit pericardial hemorrhaging unlike wild-type mice

edema ( J:166573 )

• at E16.5

Genotype
MGI:4366030

cn3

• Allelic Composition: Ppp3r1^tm2Grc/Ppp3r1^tm2Grc; Tg(GATA5-cre)1Krc/0
• Genetic Background: involves: 129S6/SvEvTac

cardiovascular system

cardiovascular system phenotype ( J:153636 )

N • mice are grossly normal and display no defects in endothelial patterning at E12.5; mice live to adulthood and are indistinguishable from wild-type littermates