All Phenotypes Tg(Hoxb6-cre)#Mku MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Hoxb6-cre)#Mku
transgene insertion, Michael R Kuehn
MGI:4366041

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Has2^tm1.1Chg/Has2^tm1.2Chg Tg(Hoxb6-cre)#Mku/0	involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL	MGI:5489766
cn2	Cyp26b1^tm2Hmd/Cyp26b1^tm1Hmd Tg(Hoxb6-cre)#Mku/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJcl * C57BL/6NCr	MGI:5466501
cn3	Isl1^tm2Sev/Isl1^tm2.1Sev Tg(Hoxb6-cre)#Mku/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5320482
cn4	Hand2^tm1Cse/Hand2⁺ Tg(Hoxb6-cre)#Mku/0	involves: 129S1/Sv * FVB/N	MGI:4417975

Allelic Composition	Has2^tm1.1Chg/Has2^tm1.2Chg Tg(Hoxb6-cre)#Mku/0
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Has2^tm1.1Chg mutation (0 available); any Has2 mutation (35 available)
Has2^tm1.2Chg mutation (0 available); any Has2 mutation (35 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal cartilage morphology ( J:194283 )

• severe cartilage reduction at P0

abnormal cartilage development ( J:194283 )

abnormal chondrocyte differentiation ( J:194283 )

• reduced chondrocyte differentiation

abnormal joint morphology ( J:194283 )

• joint positioning defects at P0 indicated by prominent changes in phalangeal cartilage nodule organization

• the interphalangeal joints are shifted perpendicularly at P0

• ectopic joints along the digit rays

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:194283 )

• impaired phalangeal mesenchymal condensation

• however, mesenchyme proliferation is normal

abnormal digit morphology ( J:194283 )

• longitudinally oriented cavities that split proximal and medial phalanges

• digit defect in the forelimb is restricted to the posterior digits

embryo

abnormal limb mesenchyme morphology ( J:194283 )

• impaired phalangeal mesenchymal condensation

• however, mesenchyme proliferation is normal

Allelic Composition	Cyp26b1^tm2Hmd/Cyp26b1^tm1Hmd Tg(Hoxb6-cre)#Mku/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJcl * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp26b1^tm1Hmd mutation (1 available); any Cyp26b1 mutation (35 available)
Cyp26b1^tm2Hmd mutation (1 available); any Cyp26b1 mutation (35 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:192725 )

N	• epidermis is normal at E18.5

limbs/digits/tail

abnormal limb development ( J:192725 )

Allelic Composition	Isl1^tm2Sev/Isl1^tm2.1Sev Tg(Hoxb6-cre)#Mku/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm2.1Sev mutation (0 available); any Isl1 mutation (36 available)
Isl1^tm2Sev mutation (1 available); any Isl1 mutation (36 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal hindlimb bud morphology ( J:184018 )

• expression analysis indicates proximal patterning defects in the hindlimb buds

hindlimb oligodactyly ( J:184018 )

• variable severity of hindlimb digit loss

• almost half of mice display hindlimbs with only 3 digits

• less severely affected mice develop 4 hindlimb digits, lacking the posterior digit 5

abnormal hindlimb zeugopod morphology ( J:184018 )

• only a single zeugopodal element, likely corresponding to the tibia, is present in most mice with 1 - 3 digits on the hindlimb

• mice with 4 digits on the hindlimb show more variability in zeugopodal defects

absent hindlimb ( J:184018 )

• in severely affected mice

embryo

abnormal hindlimb bud morphology ( J:184018 )

• expression analysis indicates proximal patterning defects in the hindlimb buds

skeleton

abnormal ischium morphology ( J:184018 )

• patterning failure

absent pubis ( J:184018 )

• patterning failure

Allelic Composition	Hand2^tm1Cse/Hand2⁺ Tg(Hoxb6-cre)#Mku/0
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1Cse mutation (0 available); any Hand2 mutation (12 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:155265 )

N	• embryos are viable to birth

embryo

embryo phenotype ( J:155265 )

N	• no visible defects are observed in extraembryonic mesoderm formation

limbs/digits/tail

abnormal limb development ( J:155265 )

• mutant neonates exhibit severe limb deformities

cardiovascular system

cardiovascular system phenotype ( J:155265 )

N	• no visible defects are observed in blood vessel formation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24