All Phenotypes Tg(Hoxb6-cre)#Mku MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Hoxb6-cre)#Mku
transgene insertion, Michael R Kuehn
MGI:4366041

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Has2^tm1.1Chg/Has2^tm1.2Chg Tg(Hoxb6-cre)#Mku/0	involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL	MGI:5489766
cn2	Cyp26b1^tm2Hmd/Cyp26b1^tm1Hmd Tg(Hoxb6-cre)#Mku/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJcl * C57BL/6NCr	MGI:5466501
cn3	Isl1^tm2Sev/Isl1^tm2.1Sev Tg(Hoxb6-cre)#Mku/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5320482
cn4	Hand2^tm1Cse/Hand2⁺ Tg(Hoxb6-cre)#Mku/0	involves: 129S1/Sv * FVB/N	MGI:4417975

Allelic Composition	Has2^tm1.1Chg/Has2^tm1.2Chg Tg(Hoxb6-cre)#Mku/0
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Has2^tm1.1Chg mutation (0 available); any Has2 mutation (35 available)
Has2^tm1.2Chg mutation (0 available); any Has2 mutation (35 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal cartilage morphology ( J:194283 )

• severe cartilage reduction at P0

abnormal cartilage development ( J:194283 )

abnormal chondrocyte differentiation ( J:194283 )

• reduced chondrocyte differentiation

abnormal joint morphology ( J:194283 )

• joint positioning defects at P0 indicated by prominent changes in phalangeal cartilage nodule organization

• the interphalangeal joints are shifted perpendicularly at P0

• ectopic joints along the digit rays

limbs/digits/tail

abnormal limb mesenchyme morphology ( J:194283 )

• impaired phalangeal mesenchymal condensation

• however, mesenchyme proliferation is normal

abnormal digit morphology ( J:194283 )

• longitudinally oriented cavities that split proximal and medial phalanges

• digit defect in the forelimb is restricted to the posterior digits

embryo

abnormal limb mesenchyme morphology ( J:194283 )

• impaired phalangeal mesenchymal condensation

• however, mesenchyme proliferation is normal

Allelic Composition	Cyp26b1^tm2Hmd/Cyp26b1^tm1Hmd Tg(Hoxb6-cre)#Mku/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJcl * C57BL/6NCr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyp26b1^tm1Hmd mutation (1 available); any Cyp26b1 mutation (35 available)
Cyp26b1^tm2Hmd mutation (1 available); any Cyp26b1 mutation (35 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:192725 )

N	• epidermis is normal at E18.5

limbs/digits/tail

abnormal limb development ( J:192725 )

Allelic Composition	Isl1^tm2Sev/Isl1^tm2.1Sev Tg(Hoxb6-cre)#Mku/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm2.1Sev mutation (0 available); any Isl1 mutation (36 available)
Isl1^tm2Sev mutation (1 available); any Isl1 mutation (36 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal hindlimb bud morphology ( J:184018 )

• expression analysis indicates proximal patterning defects in the hindlimb buds

hindlimb oligodactyly ( J:184018 )

• variable severity of hindlimb digit loss

• almost half of mice display hindlimbs with only 3 digits

• less severely affected mice develop 4 hindlimb digits, lacking the posterior digit 5

abnormal hindlimb zeugopod morphology ( J:184018 )

• only a single zeugopodal element, likely corresponding to the tibia, is present in most mice with 1 - 3 digits on the hindlimb

• mice with 4 digits on the hindlimb show more variability in zeugopodal defects

absent hindlimb ( J:184018 )

• in severely affected mice

embryo

abnormal hindlimb bud morphology ( J:184018 )

• expression analysis indicates proximal patterning defects in the hindlimb buds

skeleton

abnormal ischium morphology ( J:184018 )

• patterning failure

absent pubis ( J:184018 )

• patterning failure

Allelic Composition	Hand2^tm1Cse/Hand2⁺ Tg(Hoxb6-cre)#Mku/0
Genetic Background	involves: 129S1/Sv * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2^tm1Cse mutation (0 available); any Hand2 mutation (12 available)
Tg(Hoxb6-cre)#Mku mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:155265 )

N	• embryos are viable to birth

embryo

embryo phenotype ( J:155265 )

N	• no visible defects are observed in extraembryonic mesoderm formation

limbs/digits/tail

abnormal limb development ( J:155265 )

• mutant neonates exhibit severe limb deformities

cardiovascular system

cardiovascular system phenotype ( J:155265 )

N	• no visible defects are observed in blood vessel formation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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