Phenotypes associated with this allele

• Allele Symbol: Fasl^tm1.1Ast
• Allele Name: targeted mutation 1.1, Andreas Strasser
• Allele ID: MGI:4366050
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fasl^tm1.1Ast/Fasl^tm1.1Ast	involves: BALB/cJ * C57BL/6	MGI:4366072

Genotype
MGI:4366072

hm1

• Allelic Composition: Fasl^tm1.1Ast/Fasl^tm1.1Ast
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:153501 )

• compared with wild-type mice and Fasl^gld homozygotes

immune system

immune system phenotype ( J:153501 )

N • mice mount a normal immune response to influenza

enlarged spleen ( J:153501 )

increased immunoglobulin level ( J:153501 )

increased IgA level ( J:153501 )

increased IgE level ( J:153501 )

increased IgG level ( J:153501 )

increased IgG1 level ( J:153501 )

increased IgG2a level ( J:153501 )

increased IgG2b level ( J:153501 )

increased IgM level ( J:153501 )

decreased cytotoxic T cell cytolysis ( J:153501 )

• T cells are less efficient than wild-type cells at killing CH1 cells

increased circulating tumor necrosis factor level ( J:153501 )

• at 12 to 20 weeks

enlarged lymph nodes ( J:153501 )

increased susceptibility to systemic lupus erythematosus ( J:153501 )

• 62% of terminally ill mice exhibit systemic lupus erythematosus-like (SLE) autoimmune disease with cellular crescents, protein casts, and compliment in renal glomeruli unlike wild-type mice

• mice develop more severe SLE-like disease than Fasl^gld homozygotes

• by 57 weeks, 50% of mice develop fatal SLE-like autoimmune kidney disease compared with 15% of Fasl^gld homozygotes

increased anti-nuclear antigen antibody level ( J:153501 )

• higher than in wild-type mice and Fasl^gld homozygotes

increased anti-double stranded DNA antibody level ( J:153501 )

• higher than in wild-type mice and Fasl^gld homozygotes

glomerulonephritis ( J:153501 )

• mice develop SLE-like glomerulonephritis unlike wild-type mice and more frequently than Fasl^gld homozygotes

dermatitis ( J:153501 )

• 30% of mice develop severe dermatitis with lesions on the ears and necks unlike wild-type mice

renal/urinary system

glomerulonephritis ( J:153501 )

• mice develop SLE-like glomerulonephritis unlike wild-type mice and more frequently than Fasl^gld homozygotes

glomerular crescent ( J:153501 )

• 62% of terminally ill mice exhibit SLE-like glomerulonephritis with cellular crescents in the renal glomeruli

renal cast ( J:153501 )

• 62% of terminally ill mice exhibit SLE-like glomerulonephritis with protein casts

neoplasm

increased liver tumor incidence ( J:153501 )

• by 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs

increased histiocytic sarcoma incidence ( J:153501 )

• by 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:153501 )

• at 12 to 20 weeks

hematopoietic system

enlarged spleen ( J:153501 )

increased immunoglobulin level ( J:153501 )

increased IgA level ( J:153501 )

increased IgE level ( J:153501 )

increased IgG level ( J:153501 )

increased IgG1 level ( J:153501 )

increased IgG2a level ( J:153501 )

increased IgG2b level ( J:153501 )

increased IgM level ( J:153501 )

decreased cytotoxic T cell cytolysis ( J:153501 )

• T cells are less efficient than wild-type cells at killing CH1 cells

integument

dermatitis ( J:153501 )

• 30% of mice develop severe dermatitis with lesions on the ears and necks unlike wild-type mice

liver/biliary system

increased liver tumor incidence ( J:153501 )

• by 78 weeks, 27% of mice develop hepatic tumors with characteristics of histiocytic sarcoma with deposits in the spleen and lungs

growth/size/body

enlarged spleen ( J:153501 )