Phenotypes associated with this allele

• Allele Symbol: Hmgn3^tm1.2Mbus
• Allele Name: targeted mutation 1.2, Michael Bustin
• Allele ID: MGI:4366465
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hmgn3^tm1.2Mbus/Hmgn3^tm1.2Mbus	B6.Cg-Hmgn3^tm1.2Mbus	MGI:4366467
hm2	Hmgn3^tm1.2Mbus/Hmgn3^tm1.2Mbus	involves: 129S4/SvJae * C57BL/6J	MGI:5588103

Genotype
MGI:4366467

hm1

• Allelic Composition: Hmgn3^tm1.2Mbus/Hmgn3^tm1.2Mbus
• Genetic Background: B6.Cg-Hmgn3^tm1.2Mbus

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:153774 )

N • despite altered glucose homeostasis, insulin tolerance is normal

increased circulating glucose level ( J:153774 )

• 12% during feeding but not at fasting

decreased circulating insulin level ( J:153774 )

• 50% during feeding but not at fasting

impaired glucose tolerance ( J:153774 )

Genotype
MGI:5588103

hm2

• Allelic Composition: Hmgn3^tm1.2Mbus/Hmgn3^tm1.2Mbus
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

homeostasis/metabolism

increased circulating glucose level ( J:199604 )

• increased peak glucose during a glucose tolerance test

increased circulating testosterone level ( J:199604 )

♂ • in male mice

decreased circulating corticosterone level ( J:199604 )

♀ • in female mice

abnormal glucose tolerance ( J:199604 )

• increased fasting-induced body mass loss and peak glucose during a glucose tolerance test

behavior/neurological

decreased grip strength ( J:199604 )

increased thermal nociceptive threshold ( J:199604 )

growth/size/body

increased susceptibility to weight loss ( J:199604 )

• increased fasting-induced body mass loss during a glucose tolerance test

nervous system

decreased prepulse inhibition ( J:199604 )

• lower acoustic startle activity