All Phenotypes Dnm1l<tm1.1Hise> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnm1l^tm1.1Hise
targeted mutation 1.1, Hiromi Sesaki
MGI:4366510

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dnm1l^tm1.1Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺	involves: 129 * C57BL/6 * FVB/N * SJL	MGI:4366518
cn2	Dnm1l^tm1.1Hise/Dnm1l^tm1.1Hise En1^tm2(cre)Wrst/En1⁺	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:4366517

Allelic Composition	Dnm1l^tm1.1Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺
Genetic Background	involves: 129 * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1l^tm1.1Hise mutation (0 available); any Dnm1l mutation (44 available)
Dnm1l^tm1.2Hise mutation (0 available); any Dnm1l mutation (44 available)
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Defects in cerebellar development in Dnm1l^tm1.1Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺ and Dnm1l^tm1.2Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺ mice

cellular

abnormal Purkinje cell mitochondrial morphology ( J:153835 )

• mitochondria in Purkinje cells are enlarged compared to in wild-type cells

mortality/aging

postnatal lethality, complete penetrance ( J:153835 )

• mice die within 36 hours of birth

nervous system

abnormal cerebellum development ( J:153835 )

• at P0, cerebellum are smooth and exhibit a 60% decreased in size compared to in wild-type mice

reduced cerebellar foliation ( J:153835 )

• at P0, cerebellum lack foliation

• at P0.5, lobule fissures are barely detectable

abnormal cerebellar Purkinje cell layer ( J:153835 )

• Purkinje cells in the cerebellum are decreased in number and form a discontinuous cell layer unlike in wild-type mice

abnormal Purkinje cell mitochondrial morphology ( J:153835 )

• mitochondria in Purkinje cells are enlarged compared to in wild-type cells

decreased Purkinje cell number ( J:153835 )

• in the cerebellum

small cerebellum ( J:153835 )

• at P0, cerebellum are 60% smaller than in wild-type mice due to decreased cell proliferation

behavior/neurological

absent gastric milk in neonates ( J:153835 )

• mice die without milk in their stomach

• however, mice exhibit normal swallowing when manually fed milk

Allelic Composition	Dnm1l^tm1.1Hise/Dnm1l^tm1.1Hise En1^tm2(cre)Wrst/En1⁺
Genetic Background	involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnm1l^tm1.1Hise mutation (0 available); any Dnm1l mutation (44 available)
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Defects in cerebellar development in Dnm1l^tm1.1Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺ and Dnm1l^tm1.2Hise/Dnm1l^tm1.2Hise En1^tm2(cre)Wrst/En1⁺ mice

cellular

abnormal Purkinje cell mitochondrial morphology ( J:153835 )

• mitochondria in Purkinje cells are enlarged compared to in wild-type cells

mortality/aging

postnatal lethality, complete penetrance ( J:153835 )

• mice die within 36 hours of birth

nervous system

abnormal cerebellum development ( J:153835 )

• at P0, cerebellum are smooth and exhibit a 60% decreased in size compared to in wild-type mice

reduced cerebellar foliation ( J:153835 )

• at P0, cerebellum lack foliation

• at P0.5, lobule fissures are barely detectable

abnormal cerebellar Purkinje cell layer ( J:153835 )

• Purkinje cells in the cerebellum are decreased in number and form a discontinuous cell layer unlike in wild-type mice

abnormal Purkinje cell mitochondrial morphology ( J:153835 )

• mitochondria in Purkinje cells are enlarged compared to in wild-type cells

decreased Purkinje cell number ( J:153835 )

• in the cerebellum

small cerebellum ( J:153835 )

• at P0, cerebellum are 60% smaller than in wild-type mice due to decreased cell proliferation

behavior/neurological

absent gastric milk in neonates ( J:153835 )

• mice die without milk in their stomach

• however, mice exhibit normal swallowing when manually fed milk

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