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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bcl2l11tm1.1Boui
targeted mutation 1.1, Philippe Bouillet
MGI:4366749
Summary 6 genotypes


Genotype
MGI:4366822
hm1
Allelic
Composition		 Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Genetic
Background		 C57BL/6-Bcl2l11tm1.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

immune system
immune system phenotype ( J:153846 )
N
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

growth/size/body
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)




Genotype
MGI:4366831
ht2
Allelic
Composition		 Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 C57BL/6-Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

immune system
immune system phenotype ( J:153846 )
N
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)
increased leukocyte cell number ( J:153846 )
• increased white blood cells numbers (<2 fold)

growth/size/body
increased spleen weight ( J:153846 )
• increase in spleen weight (<2 fold)




Genotype
MGI:4366834
cx3
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice

growth/size/body
growth/size/body region phenotype ( J:153846 )
N
• grow normally

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure

renal/urinary system
renal/urinary system phenotype ( J:153846 )
N
• mice do not develop polycystic kidney disease

pigmentation
diluted coat color ( J:153846 )
• coat color becomes gray at 5 to 7 weeks of age

integument
diluted coat color ( J:153846 )
• coat color becomes gray at 5 to 7 weeks of age




Genotype
MGI:4366840
cx4
Allelic
Composition		 Bcl2tm1Dlo/Bcl2tm1Dlo
Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Genetic
Background		 B6.Cg-Bcl2tm1Dlo Bcl2l11tm1.1Boui/Bcl2l11tm2.1Boui
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2l11tm2.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Bcl2tm1Dlo mutation (0 available); any Bcl2 mutation (41 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice

hematopoietic system
hematopoietic system phenotype ( J:153846 )
N
• normal splenic structure
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
increased leukocyte cell number ( J:153846 )
• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

renal/urinary system
renal/urinary system phenotype ( J:153846 )
N
• mice do not develop polycystic kidney disease

immune system
immune system phenotype ( J:153846 )
N
• normal splenic structure
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
increased leukocyte cell number ( J:153846 )
• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice

growth/size/body
increased spleen weight ( J:153846 )
• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice




Genotype
MGI:5433579
cx5
Allelic
Composition		 Bcl2l11tm1.1Boui/Bcl2l11+
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median survival is 64 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days

neoplasm
increased T cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a rare incidence of Thy1+ T lymphoma
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mixture of sIg- pre-B lymphoma (~65%) and sIg+ B lymphoma (~35%)

hematopoietic system
increased T cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a rare incidence of Thy1+ T lymphoma
increased leukocyte cell number ( J:186117 )
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

immune system
increased T cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a rare incidence of Thy1+ T lymphoma
increased leukocyte cell number ( J:186117 )
• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a rare incidence of Thy1+ T lymphoma




Genotype
MGI:5433582
cx6
Allelic
Composition		 Bcl2l11tm1.1Boui/Bcl2l11tm1.1Boui
Tg(IghMyc)22Bri/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation (0 available); any Bcl2l11 mutation (36 available)
Tg(IghMyc)22Bri mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:186117 )
• median survival of 50 days

neoplasm
increased B cell derived lymphoma incidence ( J:186117 )
• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)

hematopoietic system
increased leukocyte cell number ( J:186117 )
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes

immune system
increased leukocyte cell number ( J:186117 )
• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory